Video lecture in Arabic: Pathophysiology and key concepts of cancer

Dr AM Fouda, MD, PhD
Professor of Clin Pharmacology
Mansoura University Faculty of Medicine, Egypt

Link to the PDF file:
https://drive.google.com/file/....d/1NWlWvDQDLlHZGpf0B

-------- Contents of this video -------------------
00:00 - Introduction
03:36 - The hallmarks of cancer
11:16 - Proliferation, differentiation and undifferentiation
16:22 - The cell cycle
23:30 - Checkpoints
25:55 - Cell cycle regulators
36:05 - Cancer genetics
36:40 - Tumor suppressor genes
37:45 - Proto- oncogenes
40:05 - Growth factors & uncontrolled Proliferation
46:26 - Cancer signaling network
48:12 - The telomere & telomerase
58:36 - Cancer therapeutic options

***SUBSCRIBE WITHIN THE NEXT 28 DAYS FOR A CHANCE TO WIN $1,000!***

Did you know only 20% of our video content is on YouTube? Try out our membership for FREE today! → https://bit.ly/39mYSUF
Try our NCLEX Prep FREE → https://bit.ly/3FHbbal

Head to https://bit.ly/39mYSUF to get access to the other 80%, along with 800+ study guides, customizable quiz banks with 3,000+ test-prep questions, and answer rationales!

Popular Playlists:
NCLEX Fluid & Electrolytes: https://bit.ly/39BSHXs
Heart Failure (CHF): https://bit.ly/2u5zfDm
Myocardial Infarction (MI): https://bit.ly/3bN9AAk
Addison’s vs. Cushing: https://bit.ly/2STvute
Diabetes Mellitus & DKA vs HHNS: https://bit.ly/37D8nbs
Cardiomyopathy: https://bit.ly/38CwcSg
IV Fluids: Hypertonic, Hypotonic & Isotonic: https://bit.ly/2P45BWx
SIADH vs Diabetes Insipidus: https://bit.ly/2wq6Bhb

Follow us on social media for more EXCLUSIVE content 👋
More Videos: https://bit.ly/37CRttH
Instagram: https://www.instagram.com/simplenursing.com_
TikTok: https://www.tiktok.com/simplenursing

Thank you for the support & for tuning in!
Remember… don’t be scared, BE PREPARED!

#chemo #Pharm #registerednurse

👉📝WANT STUDY NOTES FOR THIS PRESENTATION? 👉Join Patreon at https://www.patreon.com/speedpharmacology

Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers mechanism of action and side effects of cell cycle specifc agents including topoisomerase inhibitors (type I & type II) and microtubule inhibitors (vinca alkaloids & taxanes) as well as cell cycle nonspecfic agents including antitumor antibiotics (anthracyclines), alkylating agents (nitrogen mustards, nitrosoureas, triazines, alkyl sulfonates), platinum coordination complexes, tyrosine kinase inhibitors (targeting BCR-ABL, HER2, PDGF, VEGF, EGF receptors), and monoclonal antibodies. Antineoplastic drugs mentioned include; Irinotecan, Topotecan, Etoposide, Vincristine, Vinblastine, Vinorelbine, Paclitaxel, Docetaxel, Cabazitaxel, Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Bleomycin, Chlorambucil, Cyclophosphamide, Ifosfamide, Melphalan, Carmustine, Lomustine, Dacarbazine, Temozolomide, Busulfan, Cisplatin, Carboplatin, Oxaliplatin, Imatinib, Dasatinib, Nilotinib, Lapatinib, Sunitinib, Erlotinib, Trastuzumab, Cetuximab, Bevacizumab, and Rituximab.

Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!

Source of image showing one-electron redox cycle of anthracyclines: https://www.hindawi.com/journals/bmri/2013/751913/

Source of image showing Cisplatin activation and DNA damage induction: http://www.scielo.br/scielo.php?pid=S1807-59322018000200317&script=sci_arttext

0:00 Overview
0:47 Topoisomerase Inhibitors
2:13 Microtubule Inhibitors
4:23 Antitumor Antibiotics
6:38 Alkylating Agents
7:44 Platinum Coordination Complexes
8:42 Tyrosine Kinase Inhibitors
10:41 Monoclonal Antibodies
12:14 Side Effects

👉📝WANT STUDY NOTES FOR THIS PRESENTATION? 👉Join Patreon at https://www.patreon.com/speedpharmacology

Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers topics such as basic overview of DNA synthesis, de novo pathway for purine and pyrimidine nucleotide synthesis, mechanism of action and side effects of antimetabolites used in treatment of cancer. Covered cancer drugs include Hydroxyurea, Cladribine, Fludarabine, Gemcitabine, Cytarabine, Fluorouracil, Capecitabine, and Methotrexate.

Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!

0:00 Intro
1:18 De novo synthesis of purines
2:59 De novo synthesis of pyrimidines
4:47 Purine antimetabolites
8:29 Pyrimidine antimetabolites
12:52 Side effects

Where do I get my information from: http://armandoh.org/resource

Facebook:
https://www.facebook.com/ArmandoHasudungan

Support me:
http://www.patreon.com/armando

Instagram:
http://instagram.com/armandohasudungan

Twitter:
https://twitter.com/Armando71021105

SPECIAL THANKS:
Patreon members
FaberCastell Australia - https://www.youtube.com/user/FaberCastellGroup

What markers do I use?
FaberCastellPITTartistpens1,5
FaberCastellPITTartistpensF
FaberCastellPermanentmarkers
FaberCastellPITTartistpensbrush

​​SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channe....l/UCZaDAUF7UEcRXIFvG

My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

👉📝WANT STUDY NOTES FOR THIS PRESENTATION? 👉Join Patreon at https://www.patreon.com/speedpharmacology

Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers topics such as main stages of the cell cycle and mitosis, role of estrogen and testosterone in development of cancer, estrogen and androgen receptors, mechanism of action and side effects of anticancer enzymes and hormone therapy used in treatment of prostate and breast cancer. Covered cancer drugs include Anticancer Enzymes: Asparaginase, Pegaspargase; Aromatase Inhibitors: Anastrozole, Letrozole, and Exemestane; Selective Estrogen Receptor Modulators (SERMs): Tamoxifen and Raloxifene; Selective Estrogen Receptor Down-Regulator: Fulvestrant; Gonadotropin-Releasing Hormone (GnRH) Agonists: Leuprolide, Goserelin, and Triptorelin; GnRH Antagonist: Degarelix; Antiandrogens: Flutamide, Bicalutamide, Nilutamide, and Abiraterone.

Thanks for watching and don't forget to SUBSCRIBE, hit the LIKE button👍 and click the BELL button🔔 for future notifications!!!

0:00 The cell cycle
3:46 Anticancer enzymes
5:13 Estrogen
6:52 Anti-estrogen therapies
9:29 Testosterone
10:14 GnRH antagonists & Antiandrogens
12:18 Side effects