Neeta Somaiah, MD, assistant professor, Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the expression of NY-ESO-1 in patients with soft tissue sarcoma.

William D. Tap, MD; Richard F. Riedel, MD; Victor M. Villalobos, MD, PhD; Kristen N. Ganjoo, MD; and Jonathan C. Trent, MD, PhD, provide perspective on the management of oligometastatic disease in adult patients with soft-tissue sarcoma.

Expert panelists William D. Tap, MD; Kristen N. Ganjoo, MD; Richard F. Riedel, MD; Jonathan C. Trent, MD, PhD; and Victor M. Villalobos, MD, PhD, review clinical scenarios of resectable adult soft tissue sarcoma and the use of adjuvant or neoadjuvant therapy.

Expert panelists William D. Tap, MD; Victor M. Villalobos, MD, PhD; Kristen N. Ganjoo, MD; and Richard F. Riedel, MD, comment on the potential for use of checkpoint inhibitors in patients with soft tissue sarcoma and discuss the use of low-dose maintenance chemotherapy in high-risk rhabdomyosarcoma.

Zuzana Střížová, MD, PhD, Charles University, Prague, Czech Republic, discusses potential novel strategies for the management of soft tissue sarcomas. The tumor microenvironment makes immunotherapy unsuitable for treating patients and in an analysis of patients, macrophages were the dominant type of immune cells present. However, combining immune checkpoint inhibitors such as nivolumab and an anti-CD47 antibody has not proven to be efficacious in improving survival. This interview took place at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

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Panelists William D. Tap, MD; Mark Agulnik, MD; Damon Reed, MD; Martee L. Hensley, MD; Shreyaskumar Patel, MD; and George D. Demetri, discuss the role of chemotherapy for the various histologies in soft tissue sarcoma and the options for patients with chemotherapy-insensitive subtypes.