Small cell lung cancer (SCLC), also known as small cell carcinoma, is a highly malignant lung cancer of neuroendocrine nature. It therefore can produce a number of ectopic hormones, such as ACTH and ADH. Is is also possible to develop Lambert-Eaton myasthenic syndrome (LEMS), a characteristic paraneoplastic syndrome linked to small cell. Moreover, It may also be characterized by anti-Hu antibodies, leading to a paraneoplastic encephalitis / myelitis.

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Learn about Small Cell Lung Cancer with Pixorize's visual mnemonics. Part of our Lung Cancer playlist for the USMLE Step 1 and NBME shelf exams.

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Until recently, advancements in small cell lung cancer (SCLC) have been few and far between, and treating this aggressive type of lung cancer presents many challenges. Listen to Dr Conibear, clinical oncologist and an expert in this area, giving his perspective on the greatest challenges faced when treating people with SCLC, and his hopes for the future.

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Small cell lung cancer (SCLC) accounts for about 15-20% of lung cancers diagnosed every year in the United States. It is rarer than non-small cell lung cancer. The term “small cell” refers to the size and shape of the cancer cells as seen under a microscope. Small cell lung cancer appears as small blue cells, instead of the larger cells associated with more common forms of lung cancer. Small cell lung cancer typically starts in the middle part of the chest in a unique set of cells different to non-small cell lung cancer. Small cell lung cancer is treated differently to non-small cell lung cancer.

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This animation explains how most patients with NSCLC are treated more than 1 type of treatment. That can include with surgery, radiation therapy, or drug therapy. In various stages of lung cancer, there are also supportive treatments to ease pain and discomfort; prevent and treat side effects; help you deal with stress and anxiety; and if you have not already done so, to help you stop smoking. Palliative treatments also exist to ease symptoms and improve quality of life.

After elucidating their current status, Nancy and Dan MacMillan provide parting advice to patients and caregivers who encounter a diagnosis of small cell lung cancer.

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CURE: Combining science and humanity to make cancer understandable.

Ed hates cancer and he’ll tell you as much. He was diagnosed with non-small cell lung cancer, the same disease that took his mother. At the time he was diagnosed, Ed’s cancer had advanced to stage 3. From the moment he discovered he had cancer Ed knew he needed to go beyond traditional treatments to beat it. Ed’s oncologist asked him to consider trying IMFINZI (durvalumab). Ed’s cancer has now been eradicated and he believes immunotherapy is opening doors for patients to live longer.

Established in 1953, the Cancer Research Institute (CRI) is a 501(c)(3) nonprofit organization dedicated to harnessing our immune system’s power to control and potentially cure all cancers. Our mission: Save more lives by fueling the discovery and development of powerful immunotherapies for all types of cancer. To accomplish this, we rely on donor support and collaborative partnerships to fund and carry out the most innovative clinical and laboratory research around the world, support the next generation of the field’s leaders, and serve as the trusted source of information on immunotherapy for cancer patients and their caregivers. https://www.cancerresearch.org

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Dive into the world of lung cancer treatment, focusing on stage III non-small-cell lung cancer (NSCLC). Discover the intriguing results of a groundbreaking study that introduces a potential game-changer in the field. We explore a new cocktail of nivolumab and platinum-based chemotherapy, its impact on patients’ response rates, overall survival, and the potential for improved outcomes. Join us as we discuss the findings, the need for further research, and the exciting possibilities in the treatment of NSCLC.
Reference Article: https://www.nejm.org/doi/full/....10.1056/NEJMoa221553

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