Leukemia - Acute Lymphocytic - ALL

Deconvoluting the heterogeneous signatures of B-cell acute lymphoblastic leukemia
Deconvoluting the heterogeneous signatures of B-cell acute lymphoblastic leukemia administrator 2 Views • 2 years ago

CGC Webinar Series - June 28, 2022
Presenter: Dr. Zhaohui Gu

B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer. It consists of over 20 subtypes defined by distinct genetic alterations and gene expression profiles (GEPs), which makes accurate classification of B-ALL subtypes still challenging in clinical practice. Currently, we are analyzing the largest B-ALL cohort around the world to identify multi-omics signatures of each B-ALL subtype and aim to develop a robust B-ALL classification system based on bulk and single-cell RNA-seq. Our goal is to translate the advances in genomics research of B-ALL to precision clinical diagnosis and eventually improve the treatment strategies and outcomes for patients.

Dr. Zhaohui Gu is an assistant professor in the Department of Computational and Quantitative Medicine & Systems Biology at Beckman Research Institute of City of Hope.

Dr. Gu earned his Ph.D. degree in Bioinformatics and Cancer Biology at Shanghai Jiao Tong University. Then he did his postdoctoral training at St. Jude Children‘s Research Hospital. Dr. Gu‘s research has been recognized and supported by the American Society of Hematology (ASH) Scholar Award, The Leukemia & Lymphoma Society (LLS) Special Fellow Award, and NIH/NCI Pathway to Independence Award (K99/R00).

Dr. Gu‘s research examines the genetic basis of high-risk acute leukemia that are of unknown etiology. His work has capitalized upon a long-standing study of the genomics of acute lymphoblastic leukemia (ALL), the most common childhood cancer, that has resulted in multiple publications and influenced the understanding of the genetic basis of ALL. Specifically, his recent project using transcriptome sequencing and innovative computational pipelines has refined ALL classification into over 20 distinct subtypes and resulted in major advances in diagnostic and therapeutic approaches in ALL.

Comment: Blinatumomab for acute lymphocytic leukaemia
Comment: Blinatumomab for acute lymphocytic leukaemia administrator 2 Views • 2 years ago

Visit http://www.ecancer.org for more.

Dr Bollard (George Washington University, Washington, USA) talks to ecancertv about key abstracts showcased at ASH 2014. Here, she addresses Dr Nicola Gökbuget's study on the use of blinatumomab for the treatment of acute lymphocytic leukaemia.

Read the news story here.

Dr Bollard is also a member of the Division of the Blood and Marrow Transplantation and senior scientist at the Children National Health System's Center for Cancer and Immunology Research at Children’s Research Institute. She is the Principal Investigator and the Sheikh Zayed Institute for Pediatric Surgical Innovation.

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