Familial Adenomatous Polyposis


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What are colorectal polyps? A colorectal polyp is a small clump of epithelial cells that form a small bump or overgrowth of tissue along the lining of the colon or rectum.
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Isabel Martin on "Gastric adenomas and their management in familial adenomatous polyposis"
Authors: Isabel Martin, Victorine H. Roos, Chukwuemeka Anele et al.
Summary:
Among 726 patients with familial adenomatous polyposis (FAP), 104 (14%) had a gastric adenoma. High grade dysplasia was detected in five (5%) of these patients, while two patients had gastric cancer at initial gastric adenoma diagnosis. During follow-up, three patients were additionally diagnosed with gastric cancer. The study shows the importance of gastric endoscopic surveillance in patients with FAP.
Bibliography
Endoscopy 2021; 53: 795–801
DOI 10.1055/a-1265-2716
ISSN 0013-726X
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG, Rüdigerstraße 14,
70469 Stuttgart, Germany
Read more here: https://doi.org/10.1055/a-1265-2716


What is FAP? What are the symptoms, and how do you deal with it? Patient Coach, Corwin Crandell has the answers!
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Episode 95
In this episode, author Laura Kieger and her son Dr. Alexander Kieger share their family’s courageous, century-long struggle with a rare genetic cancer syndrome, familial adenomatous polyposis. Familial adenomatous polyposis is a rare genetic cancer predisposition syndrome caused by a deletion mutation in the APC gene on chromosome 5. By the age of 40, nearly 99% of untreated patients will develop cancer. This is the dark shadow that has lingered over the Kieger family since at least 1911 when Mary Regan Baker was seen at Mayo Clinic in Rochester, Minnesota for symptoms of a disorder that would become commonplace in her descendants. Through deeply touching personal stories of love, heartbreak and hope, Laura’s book, Summer’s Complaint, explores the meaning of family and how tragic loss leads to the remaking of life in the face of a rare genetic mutation.
Laura Kieger obtained a Bachelor of Arts degree from the University of Minnesota (Twin Cities) and a Master’s degree in Human Development from St. Mary’s University. Dr. Alexander Kieger is a vascular and interventional radiologist at Vascular Institute of Virginia. He graduated from Drake University with a Bachelor of Arts degree in Biochemistry and Cell and Molecular Biology. He obtained his Doctor of Medicine from Northwestern University’s The Feinberg School of Medicine.
For more information about this episode, check out our blog post here:
http://dnapodcast.com/episodes..../2018/12/7/95-kieger
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DNA Today is a podcast and radio show exploring genetics’ impact on health through conversations with leaders in genetics like genetic counselors, researchers, doctors, and patient advocates. The show started in 2012 and features over 135 episodes. DNA Today has been nominated in the Podcast Awards in 2015, 2016 and 2019.
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