Cholangiocarcinoma is a type of cancer that originates in the cells lining the bile ducts, which are the tubes that carry bile from the liver to the small intestine. The symptoms, investigations, and treatment of cholangiocarcinoma can vary depending on the location and stage of the cancer.
@DrAshishSachan
Symptoms:
1. Jaundice (yellowing of the skin and eyes)
2. Abdominal pain or discomfort
3. Unexplained weight loss
4. Fatigue
5. Itchy skin
6. Pale stools and dark urine
7. Loss of appetite
8. Fever

Investigations:
1. Imaging tests: These may include abdominal ultrasound, computed tomography (CT) scan, magnetic resonance imaging (MRI), or positron emission tomography (PET) scan to visualize the bile ducts and identify any abnormalities.
2. Endoscopic retrograde cholangiopancreatography (ERCP): This procedure combines endoscopy and X-rays to examine the bile ducts and take tissue samples for biopsy.
3. Biopsy: A sample of tissue is taken from the suspicious area to confirm the diagnosis of cholangiocarcinoma and determine the type and stage of cancer.
4. Blood tests: These may include liver function tests and tumor markers such as CA 19-9.

Treatment:
The treatment options for cholangiocarcinoma depend on the stage and location of the cancer, as well as the overall health of the patient. They may include:
1. Surgery: This is the preferred treatment when possible. It may involve removing part of the bile duct, the gallbladder, and surrounding tissues. In some cases, a liver transplant may be recommended.
2. Radiation therapy: High-energy beams are used to kill cancer cells or shrink tumors. It can be used before surgery to shrink tumors or after surgery to destroy remaining cancer cells.
3. Chemotherapy: Drugs are used to kill cancer cells throughout the body. Chemotherapy may be given before surgery (neoadjuvant), after surgery (adjuvant), or in advanced cases to help control symptoms.
4. Targeted therapy: This involves using drugs that specifically target certain genetic mutations or abnormal proteins in cancer cells.
5. Palliative care: This focuses on managing symptoms and improving the quality of life for patients with advanced cholangiocarcinoma.

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In this webcast from the '2019 ESMO World Congress on Gastrointestinal Cancer', Dr. Michel P. Ducreux discusses molecular alterations and new therapeutic advances in the treatment of bile duct cancer.

© 2019 Imedex, an HMP Company

Dr. Daniel Catenacci, gastrointestinal cancer care expert, reviews the following case question, incorporating updates from the 2022 ASCO annual conference that have changed the standard of care.

What molecular testing is currently appropriate for metastatic or locally advanced unresectable biliary tract cancers?
A. MSI status for immunotherapy
B. BRAF mutation for anti-BRAF therapy
C. FGFR2 fusion/translocation for anti-FGFR2 therapy
D. HER2 amplification/overexpression for anti-HER2 therapy
E. IDH1 mutation for anti-IDH1 therapy
F. HER2 low expression or no expression/ISH+
G. None of the above
H. All of the above
I. All of the above except HER2 low expression or no expression/ISH+

The answer is I) all of the above, as each of these molecular subgroups have derived benefit from respective matched therapies. The question of low level HER2 expression or IHC0/ISH+ remains to be defined with larger prospective studies.

Find more oncology education opportunities at www.totalhealthconferencing.com

Sal was first diagnosed with breast cancer, and then later with bile duct cancer, which she was told was incurable.

“How are we going through this again? We’ve been through this – we’ve done our time.”

Sal entered a hospice in August 2020, and sadly died in September 2020.1 in 2 people in the UK will get cancer during their life time. Every pound you give helps speed up life-saving cancer research, bringing treatments to people who need them, faster.

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Early signs we see and what they mean in Cholangiocarcinoma better known as Bile Duct Cancer

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Bile ducts are thin tubular structures which help carry bile (a liquid that helps in fat digestion) produced by liver from the liver to gallbladder and intestines. Symptoms of bile duct cancer include jaundice (yellow skin and eyes), usually associated with light colored stools, and itching, weight loss, weakness, and so on.
After physical examination, a battery of blood tests, CT, MRI (MRCP) amongst others usually help in diagnosis. The treatment for this diesase needs a careful planning with implementation of the planned steps of treatment with clock work precision.
After biliary drainage and portal vein embolization (when needed), surgery entailing the removal of a part of liver and the involved bile ducts can help ensure cure with good quality of life.
Watch this video to see the story of a patient of bile duct cancer who had surgery with us and is doing good in life.
bile duct cancer (cholangiocarcinoma) can be cured. Nothing is incurable. one must not lose hope and motivation.
# क्या पित्त नली का कैंसर इलाज योग्य है?
# स्टेज 4 पित्त नली कैंसर क्या है?
#What are the signs of cancer of the bile duct?
# Bile duct cancer causes
# Bile duct cancer survival rate

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Best advanced care and treatment of liver, pancreas and bile duct cancers at:
Dr Vivek Mangla
MBBS, MS (Surgery), FAIS, MCh (GI Surgery, AIIMS), FACRSI
Director (Gastrointestinal and HPB Surgical Oncology)
Max Institute of Cancer care
Max Hospitals Vaishali & Patparganj, Delhi-NCR
Room NO. 1001, East Wing, Ground Floor, Max Hospital Patparganj
Room No. 2623, 6th floor, Tower2 Max hospital Vaishali or
Specialist clinic , D-23 Rajouri garden, Delhi
Contact us: 9671121837
Whatsapp : 9868352888

About the Doctor:-
Dr. Vivek Mangla
Director, GI & HPB OncoSurgery

Dr. Vivek Mangla is an expert in gastrointestinal, liver, pancreas, and gall bladder surgery. He has been working for more than 15 years in the field of laparoscopic surgery, cancer surgery and complex endoscopic surgery in Delhi. He has been awarded at national and international levels for his outstanding work in gastrointestinal surgery.

He has completed his MBBS and MS from Maulana Azad Medical College, New Delhi. He earned his Mch degree in the treatment of diseases related to the gastrointestinal system from the prestigious All India Institute of Medical Sciences, New Delhi.

He is also trained at reputed high-volume centres across USA and UK in laparoscopic and robotic surgery of colorectal cancers, hepatectomy, liver transplantation and the latest safe treatment of diseases of the stomach and pancreas.

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🚩 Major Services:- Dedicated super speciality surgical care for both benign and malignant gastrointestinal, liver and pancreatic diseases including gallbladder stones, bile duct stones and strictures, choledochal cysts, inflammatory bowel disease (ulcerative colitis, Crohn’s disease), liver tumors, stomach cancer (Gastric Cancer), colorectal cancer, colonic diverticular disease and its complications, acute and chronic pancreatitis, pancreatic cancer, gallbladder cancer etc. Specialized care for patients with failed previous surgery for abdominal problems, and pancreas surgery.

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"If you look at me, no one thinks that I am a stage four cancer patient." - Stephanie

In this episode of Medical Stories, we meet Stephanie, 52, a powerful figure recognized for her skills and contributions to the international human rights field. Her work has changed lives. Now she is counting on the work of medical scientists to change hers. Stephanie noticed discomfort and other symptoms while on vacation. This led to a devastating diagnosis of a very rare form of gastrointestinal cancer called Cholangiocarcinoma or bile duct cancer, of which there are about 8,000 cases in the United States per year.

Today treatment opportunities are providing hope and encouragement. Stephanie is attacking her illness with everything that science has made available to her, along with positive determination and her deep commitment to how the mind affects the body.

Featuring renowned expert: Lipika Goyal, MD, Director of the Gastrointestinal Oncology Program at Stanford Cancer Institute

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