Vitamin B6 Addiction in Acute Myeloid Leukemia
Presented By:
Justin R. Cross, PhD
Speaker Biography:
Director, Donald B. and Catherine C. Marron Cancer Metabolism Center
Webinar:
Vitamin B6 Addiction in Acute Myeloid Leukemia
Webinar Abstract:
Cancer cells rely on altered metabolism to support their proliferation. We performed a CRISPR/Cas9 functional genomic screen targeting a library of metabolic enzymes and identified PDXK - the enzyme that produces pyridoxal phosphate (PLP) from vitamin B6 - as an acute myeloid leukemia (AML)-selective dependency. PDXK kinase activity was required for both PLP production and AML cell proliferation. Additionally, pharmacological blockade of the vitamin B6 pathway recapitulated PDXK disruption. Metabolomic profiling revealed AML cells have unique dependencies on vitamin B6-dependent metabolic reactions and disruption of this metabolism impaired their proliferation. Our work identifies the vitamin B6 pathway as a pharmacologically actionable dependency in AML.
Earn PACE Credits:
1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/ms/we....binar/metabolic-repr
2. Watch the webinar on YouTube or on the LabRoots Website (https://www.labroots.com/ms/we....binar/metabolic-repr
3. Click Here to get your PACE credits (Expiration date: October 01, 2022): (https://www.labroots.com/credi....t/pace-credits/4434/
-
Category
No comments found