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TxN2aMx P16+ UNKNOWN PRIMARY (metástase cervical de primário oculto).
A female patient with a neck mass measuring 5 cm on palpation. The patient had a computed tomography (CT) imaging from skull base to diaphragm as part of the assessment of a suspicious SCC of the head and neck. It assessed and confirmed the extent of the lymphadenopathy, and discarded a second primary or other metastasis. A PET-CT showed hypermetabolic activity in the neck, and in both palatine tonsils. The FNA did not clarify the diagnosis. A core biopsy with immuno-histochemical techniques revealed the malignant nature of the disease and overexpression of HPV (p16 +). Panendoscopy was not helpfull to define primary site.
We performed TORS to remove both palatine and lingual tonsils. Frozen section anatomy confirmed the primary site at the right palatine tonsil, with a narrow margin. In the same surgery we improve negative margin area. Radical neck dissection revealed 3 positive nodes / 51.
Instead of chemorradiation, now we have a patient to apply ECOG 3311 (50 gy at tonsil site + 60gy in the neck).
Paciente do sexo feminino com massa cervical medindo 5 cm à palpação. A paciente fez uma tomografia computadorizada (TC) da base do crânio ao diafragma como parte da avaliação de um CEC suspeito de cabeça e pescoço. Ele avaliou e confirmou a extensão da linfadenopatia e descartou uma segunda metástase.
A PET-CT mostrou atividade hipermetabólica no pescoço e em ambas as tonsilas palatinas. A FNA não esclareceu o diagnóstico. Uma core biópsia com técnicas imuno-histoquímicas revelou a natureza maligna da doença e a superexpressão do HPV (p16+).
A panendoscopia não foi útil para definir o sítio primário.
Realizamos TORS para remoção de tonsilas palatinas e linguais. A anatomia de congelação confirmou o sítio primário na tonsila palatina direita, com margem estreita. Na mesma cirurgia melhoramos a margem negativa.
A dissecção radical do pescoço revelou 3 nódulos positivos / 51 total.
Em vez de quimiorradiação, agora temos um paciente para aplicar ECOG 3311 (50 gy no local da amígdala + 60gy no pescoço).
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