Tumor Microenvironment in Chronic Lymphocytic Leukemia through Transcriptomic Analysis
Chronic Lymphocytic Leukemia (CLL) is one of the most commonly diagnosed lymph-proliferative disorders in adults across the world. It involves the uncontrolled proliferation of CD5 & CD19 containing antigen of the clonal B-cell population. The clinical behaviour and molecular mechanisms of the disease are highly heterogeneous in nature. The biological processes driving the progression of the disease are not clearly understood with conventional mechanism. Rapid advancements in Next Generation Sequencing (NGS) allows for single-cell and whole genome sequencing to characterise the various transcriptomic elements that are differentially expressed between the normal and leukemic cells. The tumor microenvironment has been receiving increasing attention in recent times due to its ability to interact with the tumour-derived signalling pathways and anti-tumor functions of the B-cell precursor lymphoblasts by promotion of tumor growth and in turn being driven by the inflammatory responses of peripheral blood (PB) and Lymph Node (LN) samples of CLL. The current article focuses on studying the interdependencies of Immune Microenvironment in the progression and prognosis of CLL. Thus the project discusses the clinical characteristics of CLL in patient data through its interdependencies on the tumor microenvironment which can be further used as biomarkers and novel therapeutic strategies for enhanced disease treatment.
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