The Hallmarks of Aging: Epigenetic Alterations | LifeXtenShow

Did you know that your genes can be switched on and off? They can, and while this is mostly okay, it's also one of the reasons we age—and we just might be able to do something about it.

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Music:

Intro jingle courtesy of Kevin MacLeod - Incompetech.com

"Hungarian Rhapsody N. 2", by Franz Liszt, licensed under cc-by-sa Germany license by Bernd Krueger, http://www.piano-midi.de

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Sources & further reading:

The hallmarks of aging:
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC38361

Influence of smoking on epigenetics:
Lee, K. W., & Pausova, Z. (2013). Cigarette smoking and DNA methylation. Frontiers in genetics, 4, 132. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC37132

Talikka, M., Sierro, N., Ivanov, N. V., Chaudhary, N., Peck, M. J., Hoeng, J., ... & Peitsch, M. C. (2012). Genomic impact of cigarette smoke, with application to three smoking-related diseases. Critical reviews in toxicology, 42(10), 877-889. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC34914

Knopik, V. S., Maccani, M. A., Francazio, S., & McGeary, J. E. (2012). The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Development and psychopathology, 24(4), 1377-1390. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC35810

Influence of chronic stress on epigenetics:
Hunter, R. G. (2012). Epigenetic effects of stress and corticosteroids in the brain. Frontiers in cellular neuroscience, 6, 18. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC33298

Cunliffe, V. T. (2016). The epigenetic impacts of social stress: how does social adversity become biologically embedded?. Epigenomics, 8(12), 1653-1669. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC52890

Rusconi, F., & Battaglioli, E. (2018). Acute stress-induced epigenetic modulations and their potential protective role toward depression. Frontiers in molecular neuroscience, 11, 184. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC59906

Chromatin remodeling and transcriptional alterations in progeroid syndromes:
Oberdoerffer, P., & Sinclair, D. A. (2007). The role of nuclear architecture in genomic instability and ageing. Nature reviews Molecular cell biology, 8(9), 692. (https://www.nature.com/articles/nrm2238)

Epigenetic changes in aging:
Kane, A. E., & Sinclair, D. A. (2019). Epigenetic changes during aging and their reprogramming potential. Critical reviews in biochemistry and molecular biology, 54(1), 61-83. (https://www.tandfonline.com/do....i/abs/10.1080/104092

Euchromatin and heterochromatin in progeroid syndromes and aging:
Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., ... & Yuan, T. (2015). A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science, 348(6239), 1160-1163. (https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC44946

Scaffidi, P., & Misteli, T. (2006). Lamin A-dependent nuclear defects in human aging. Science, 312(5776), 1059-1063. (https://www.ncbi.nlm.nih.gov/pubmed/16645051)

Partial cellular reprogramming with OSKM:
Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., ... & Araoka, T. (2016). In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell, 167(7), 1719-1733. (https://www.cell.com/fulltext/....S0092-8674(16)31664-

Alternative partial cellular reprogramming approach by Turn.Bio:
Sarkar, T. J., Quarta, M., Mukherjee, S., Colville, A., Paine, P., Doan, L., ... & Rando, T. A. (2019). Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells. bioRxiv, 573386. (https://www.biorxiv.org/conten....t/10.1101/573386v1.f

https://www.leafscience.org/an-interview-with-prof-vittorio-sebastiano-of-turn-bio/ https://www.leafscience.org/partial-cellular-reprogramming-to-reverse-cellular-aging/
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#Aging #Epigenetics #Biology #Science #Rejuvenation #LifeExtension

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• Category

  Werner Syndrome