Summit study: safety & efficacy of bezuclastinib in patients with nonadvanced systemic mastocyto

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07/09/23

Prithviraj Bose, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, shares some insights into the ongoing Summit study (NCT05186753), which is evaluating the safety and efficacy of bezuclastinib, a potent KIT D816V inhibitor, in adult patients with nonadvanced systemic mastocytosis (NonAdvSM). Dr Bose highlights the advantages of this agent, including its high selectivity to the target and minimal interaction with the blood-brain barrier (BBB). These features may allow bezuclastinib to inhibit KIT D816V while minimizing adverse events (AEs) in the central nervous system (CNS) as well as off-target AEs. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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