Shocking, rare disease: Disturbing photos show the gruesome effects of xeroderma pigmentosum

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06/27/23

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The largest single group of people suffering a genetic disease known as xeroderma pigmentosum, or XP, live in Araras in central Brazil, where their skin rapidly breaks down under the tropical sun.

This disease places an enormous burden on this community that relies on farming and outdoor work to survive. UV rays can penetrate the skin's thick epidermis to reach inner skin cells.

While most individuals naturally recover from exposure to sunlight, people born with the skin disorder do not have the ability to repair UV damages. Those born with the skin disorder are highly sensitive to UV rays, developing freckles and small lumps at a young age. Many eventually die from skin tumors.

The village was founded by just a few families in which several members were carriers of the disease. Researchers say that the geographic isolation of the region made marriages between cousins common, greatly increasing the incidence of XP.

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