Redefining kidney cancer
Exciting new research by Cancer Research UK scientists at the Francis Crick Institute has investigated the evolution of kidney cancer - how it grows from a small clump of diseased cells into a tumour, and how that tumour can start to spread.
Their evolutionary mapping of kidney cancer has helped them reclassify the disease into seven distinct subtypes, each with their own evolutionary characteristics. And the traits from these seven subtypes can help doctors get a better idea of which cancers have a higher risk of coming back after treatment and spreading.
References:
-Campbell, Peter J et al., Cell (2018): "Timing the landmark events in the evolution of clear cell renal cell carcinoma" DOI: 10.1016/j.cell.2018.02.020
- Swanton, Charles et al., Cell (2018): "Deterministic evolutionary trajectories influence primary tumour growth, TRACERx Renal" DOI: 10.1016/j.cell.2018.03.043
- Swanton, Charles et al., Cell (2018): "Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal" DOI: 10.1016/j.cell.2018.03.057
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