Neurofibromatosis | scope in homeo | ന്യൂയോഫിറോമാറ്റോസിസ് | ഹോമിയോ |

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07/10/23

Neurofibromatosis is caused by genetic defects (mutations) that either are passed on by a parent or occur spontaneously at conception. The specific genes involved depend on the type of neurofibromatosis: NF1 . The NF1 gene is located on chromosome 17.

MPNST and glioma were found to be the two most common causes of reduced life expectancy among NF1 patients. In Kaplan–Meier analyses the median survival for NF1 patients was shown to be 71.5 years, with women living ∼7.4 years longer than men.

Although some cutaneous neurofibromas arise in childhood, most start appearing during or after the teenage years. Freckling usually appears by 3 to 5 years of age.