Metastatic group 3 medulloblastoma driven by PRUNE1 targeting NME1–TGF-b–OTX2–SNAIL

1 Views
administrator
administrator
07/06/23

READ THE PAPER: http://bit.ly/2osb7F0
The molecular events underlying dissemination of group 3 medulloblastoma remain elusive. Ferrucci et al. show that PRUNE1 overexpression enhances the canonical TGF-β cascade, upregulates OTX2 and SNAIL, and inhibits the tumour suppressor PTEN. They describe anti-metastatic properties of an anti-PRUNE1 drug, and identify further deleterious gene variants as therapeutic targets.

Show more
0 Comments Sort By

    No comments found

    Facebook Comments

    Up next

    Emerging AL amyloidosis treatments: immunotherapies & targeting amyloid plaque deposits
    00:02:30
    Emerging AL amyloidosis treatments: immunotherapies & targeting amyloid plaque deposits
    administrator
    4 Views
    State of the Science: Treatment for Metastatic Anal Cancer
    00:16:03
    State of the Science: Treatment for Metastatic Anal Cancer
    administrator
    3 Views
    Clinical Trials for Recurrent and Metastatic Anal Cancer with Cathy Eng, MD, FACP, FASCO
    00:13:35
    Clinical Trials for Recurrent and Metastatic Anal Cancer with Cathy Eng, MD, FACP, FASCO
    administrator
    2 Views
    Metastatic colorectal cancer to the lungs
    00:02:23
    Metastatic colorectal cancer to the lungs
    administrator
    2 Views
    Standard of Care for Recurrent and Metastatic Anal Cancer with Paul Romesser, MD
    00:10:25
    Standard of Care for Recurrent and Metastatic Anal Cancer with Paul Romesser, MD
    administrator
    2 Views
    How a support group helped me during anal cancer treatment
    00:01:22
    How a support group helped me during anal cancer treatment
    administrator
    2 Views
    Management and Care after a Mastectomy CANSA Netcare M Store Support Group 23 Oct 2021
    00:57:54
    Management and Care after a Mastectomy CANSA Netcare M Store Support Group 23 Oct 2021
    administrator
    2 Views
    Metastatic Colorectal Cancer
    00:01:39
    Metastatic Colorectal Cancer
    administrator
    1 Views
    Metastatic Spinal Cancer
    00:01:31
    Metastatic Spinal Cancer
    administrator
    2 Views
    STEAP1 targeting CAR-T therapy for solid tumors
    00:02:17
    STEAP1 targeting CAR-T therapy for solid tumors
    administrator
    0 Views
    STEAP1 targeting CAR-T therapy for solid tumors
    00:02:17
    STEAP1 targeting CAR-T therapy for solid tumors
    administrator
    2 Views
    Ependymoma ,Medulloblastoma,Rosette,Schannomma ,Imo Bodies 1
    00:28:15
    Ependymoma ,Medulloblastoma,Rosette,Schannomma ,Imo Bodies 1
    administrator
    3 Views
    HIPEC Q&A on Regional Perfusion for Metastatic Cancer with Dr. Brett Schipper | HipecTreatment.c
    00:21:00
    HIPEC Q&A on Regional Perfusion for Metastatic Cancer with Dr. Brett Schipper | HipecTreatment.c
    administrator
    2 Views
    A Rare Case of Metastatic Cervical Cancer in Twin Pregnancy - Annie Xu
    00:07:15
    A Rare Case of Metastatic Cervical Cancer in Twin Pregnancy - Annie Xu
    administrator
    4 Views
    2020 Targeting ALK - From Discovery to Frontline Treatment
    00:45:52
    2020 Targeting ALK - From Discovery to Frontline Treatment
    administrator
    5 Views
    Targeting of NSCLC in 2011
    00:39:36
    Targeting of NSCLC in 2011
    administrator
    2 Views
    Targeting of NSCLC in 2011 by Alice Shaw, MD, PhD
    00:39:36
    Targeting of NSCLC in 2011 by Alice Shaw, MD, PhD
    administrator
    4 Views
    Novel Therapies for Metastatic Melanoma - Omid Hamid MD
    00:25:54
    Novel Therapies for Metastatic Melanoma - Omid Hamid MD
    administrator
    1 Views
    Metastatic Melanoma: Novel Treatments, Adverse Event Management, and Patient Education
    01:25:31
    Metastatic Melanoma: Novel Treatments, Adverse Event Management, and Patient Education
    administrator
    1 Views