Lymphoma: Overview of Classification

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07/09/23

This Harvard Medical School Continuing Education video examines these key questions: how are lymphomas classified, and what are the key features of lymphomas?

Dr. Connor Johnson, MD, an oncologist at Massachusetts General Hospital, compares the traditional system for classifying lymphomas, which begins with separating them into Hodgkins and non-Hodgkins buckets, to a more easily digestible framework of lymphoma subtype archetypes that groups indolent, aggressive and very aggressive lymphomas together. The presentation and histology of several important lymphoma subtypes are reviewed.

00:00 | Introduction
00:34 | Traditional lymphoma classification
01:42 | Lymphoma subtype archetypes
03:02 | Follicular lymphoma
03:45 | Diffuse large B-cell lymphoma (DLBCL)
04:48 | Burkitt lymphoma
05:42 | Hodgkin lymphoma
06:35 | Summary

This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. It was edited by affiliate physicians of Harvard Medical School, Arielle J Medford, MD, Senior Medical Oncology Fellow, Dana-Farber Cancer Institute and Anna Handorf, MD, Research Fellow in Pediatrics, Massachusetts General Hospital.

References:
Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 4th ed. International Agency for Research on Cancer; 2017.

Casulo C. How I manage patients with follicular lymphoma. Br J Haematol. 2019;186(4):513-523. doi:10.1111/bjh.16011

Sehn LH, Salles G. Diffuse Large B-Cell Lymphoma. N Engl J Med. 2021;384(9):842-858. doi:10.1056/NEJMra2027612

Lap CJ, Nassereddine S, Dunleavy K. Novel Biological Insights and New Developments in Management of Burkitt Lymphoma and High-Grade B-Cell Lymphoma. Curr Treat Options Oncol. 2021;22(7):60. Published 2021 Jun 7. doi:10.1007/s11864-021-00857-w

Crombie JL, LaCasce AS. Current considerations in AYA Hodgkin lymphoma. Br J Haematol. 2019;184(1):72-81. doi:10.1111/bjh.15640

Notice: At this time, the content in this video is not accredited.