Human non-hodgkin lymphoma cured by new nuclear medicine therapy
#molecularimaging #cancerresearch #tumorcells
A new nuclear medicine therapy can cure human non-Hodgkin lymphoma in an animal model, according to research published in the The Journal of Nuclear Medicine. A single dose of the radioimmunotherapy, [177Lu] Lu-ofatumumab, was found to quickly eliminate tumor cells and extend the life of mice injected with cancerous cells for more than 221 days (the trial endpoint), compared to fewer than 60 days for other treatments and just 19 days in untreated control mice. In the study researchers labeled ofatumumab, a recently developed anti-CD20 fully human antibody, with 177Lu, a widely used therapeutic radioisotope that can kill cancer cells. They then determined the in vitro characteristics of [177Lu]Lu-ofatumumab, estimated human dosimetry, and evaluated its therapeutic effectiveness for non-Hodgkin lymphoma in a mouse model.
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