How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7

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07/30/23

How do drugs like Ozempic (semaglutide) cause weight loss? What happens when someone comes off of these drugs? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects.

Link to episode on neuroscience of appetite regulation:
https://www.youtube.com/watch?v=i3RzV9vS_FA

#healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss

Chapters:

00:00 - Intro
01:31 - What Does GLP-1 Do?
02:08 - GLP-1 Receptors in the Brain
02:52 - Activating the GLP-1 "Switch" (Receptors)
04:13 - Clinical Trials - Semaglutide for Weight Loss
05:29 - Semaglutide and Heart & Metabolic Health
05:54 - For How Long Does Semaglutide Work?
06:35 - Weight Regain After Stopping Semaglutide
08:24 - Side Effects of GLP-1 Receptor Agonists
09:37 - Take-Home Points
10:20 - Outro

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References & Show Notes:
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The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.