Gleason 9 Prostate Cancer: Cure Rates, Treatments, New Approaches | Mark Scholz, MD | PCRI

Gleason 9 and 10 prostate cancers represent, potentially, the most dangerous of the newly diagnosed, non-metastatic, forms of prostate cancer because they have the highest likelihood of distant spread. However, a significant portion of these men will still be able to achieve a cure or durable remission with the proper treatment. Even more good news is that the recently FDA-approved PSMA PET scan offers men markedly improved staging compared to what was available before, which means a patient is more likely to receive appropriate treatment upfront. Here, PCRI's Alex asks Medical Oncologist Mark Scholz, MD, all about Gleason 9 and 10 prostate cancer in 2023.

0:06 In Gleason 9 prostate cancer, what is the significance of the volume of cancer graded as Gleason 5 and the amount graded as Gleason 4?

2:41 What are the cure rates in men with Gleason 9 prostate cancer?

3:17 Is focal therapy an option for Gleason 9?

4:39 Does radical treatment make more sense for a Gleason 9 to have the best chance of achieving a cure?

5:16 If someone with localized Gleason 9 is considering focal treatment, should they also have hormone therapy since it is a high-risk cancer?

7:00 Which forms of radiation are most effective for Gleason 9?

7:56 The two types of brachytherapy are "permanent" and "temporary" seed implants. Is one any better than the other?

8:23 How common is Gleason 10?

8:58 What is the "standard" protocol for Gleason 9 and 10 prostate cancer?

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  Prostate Cancer