Genetics of Cancer - The Ewing's Sarcoma Story

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09/10/23

Cancer sucks, but knowledge is power, so we are powering through with another video! This time I am talking about the genetics of Ewing's Sarcoma. Learn about the chromosomes, genes, translocations, and proteins involved in creating cancer cells.

Main takeaways to remember:
- 85% of Ewing's Sarcoma tumors have t(11, 22) translocation - that is a genetic translocation between the 11th and the 22nd chromosome
- the involved genes are EWSR1 and FLI1
- together they create a new protein, EWS/FLI1

Timestamps:
0:00 Intro
1:20 Genetics 101
2:03 Translocation t(11,22)
3:50 Protein EWS/FLI1
4:54 Lack of Precision Medicine
5:48 Conclusion