Chronic Eosinophilic Leukemia

Chronic eosinophilic leukemia (CEL) is a myeloproliferative disease, in which an autonomous,clonal proliferation of eosinophilic precursors results In
persistently increased numbers of eosinophils in the blood, bone marrow
and peripheral tissues. Organ damage occurs as a result of leukemic infiltration or
the release of cytokines. enzymes or other proteins by the eosinophils. In CEL. the eosinophil count is ≥1500/mm3 in the blood. There is no Ph chromosome or BCR/ABL
fusion gene. and there are 5-19% blasts in the blood or bone marrow.

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