Blood eosinophilia - a biomarker for all-cause COPD mortality - Video abstract [ID 245056]

Video abstract of an original research "Blood Eosinophilia and Its Stability in Hospitalized COPD Exacerbations are Associated with Lower Risk of All-Cause Mortality" published in the open access International Journal of Chronic Obstructive Pulmonary Disease by Ying Zhang, Li-Rong Liang, Shu Zhang et al.

Purpose: Peripheral blood eosinophilic counts are susceptible to many factors and have
variability over time. There are limited studies on association of blood eosinophilia with
long-term mortality of chronic obstructive pulmonary disease (COPD) patients and these
results remain controversial. Our aims were to explore the association of blood eosinophilia
at index hospitalization and stability of blood eosinophilia stability over 5 years
with all-cause mortality of patients hospitalized for acute exacerbation of COPD
(AECOPD).

Patients and Methods: Eight hundred twenty-nine patients hospitalized for AECOPD
between 2013 and 2014 were included in this study and grouped into two groups according
to blood eosinophil with 150 cells/μL used as the cutoff value to form eosinophilic and noneosinophilic
groups. Two hundred forty-one COPD inpatients with at least three blood
eosinophils measured from different hospitalizations were used for analysis of longitudinally
eosinophilic stability and divided into three groups according to the same cutoff value:
predominantly (PE), intermittently (IE) and rarely (RE) eosinophilic groups. Cox regression
analysis was used to determine the association of blood eosinophilia and all-cause mortality.
Results: In patients hospitalized for AECOPD, 261 (31.5%) at baseline and 41 (17%)
based on at least three measurements of blood eosinophils had increased blood eosinophils.
For all-cause mortality, eosinophilic COPD patients at index hospitalization had a lower
all-cause mortality compared with non-eosinophilic COPD patients (hazard ratio 0.77, 95%
confidence interval 0.6–0.99, P=0.04). In patients readmitted for AECOPD by longitudinal
eosinophil stability, with the RE group used as reference, the PE group was associated with
a lower all-cause mortality of AECOPD patients (hazard ratio 0.43, 95% confidence
interval 0.22–0.85, P=0.016), compared to the IE group (hazard ratio 0.72, 95% confidence
interval 0.47–1.11, P=0.133).

Conclusion: Patients with increased eosinophils (using eosinophil 150 cells/μL as a cutoff
value), especially predominantly increased eosinophil levels based on multiple measurements,
had a lower risk of all-cause mortality. Blood eosinophilia can be used as a biomarker
in hospitalized COPD exacerbations for predicting the risk of all-cause mortality.

Read the full paper here: https://www.dovepress.com/bloo....d-eosinophilia-and-i

• Category

  Leukemia - Eosinophilic