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Hereditary Leiomyomatosis and Renal Cell Cancer

W. Marston Linehan and Patient Discuss HLRCC at NIH Clinical Center
W. Marston Linehan and Patient Discuss HLRCC at NIH Clinical Center administrator 3 Views • 2 years ago

Read the full story: http://irp.nih.gov/our-researc....h/research-in-action

W. Marston Linehan, M.D., investigates kidney cancer gene pathways to find new treatment strategies. In this video, he discusses hereditary leiomyomatosis and renal cell cancer (HLRCC) with Eric, a patient participating in research at the NIH Clinical Center. Dr. Linehan is Chief of the Urologic Oncology Branch in the Center for Cancer Research (CCR) at the National Cancer Institute (NCI).

A Genitourinary Surgeon Discusses Hereditary Kidney Cancers
A Genitourinary Surgeon Discusses Hereditary Kidney Cancers administrator 3 Views • 2 years ago

In today's #KidneyCANDID, Dr. Brandon Manley from the Moffitt Cancer Center in Tampa, Florida, discusses hereditary renal cancers. The most common is von Hippel-Lindau syndrome, though it is not the only hereditary #kidneycancer. Dr. Manley offers advice for understanding the diagnosis, finding support in patient groups, and connecting with genetic specialists to understand the impact of your diagnosis on family members.

If you're facing kidney cancer, you're not alone. KidneyCAN has an entire community of patients and caregivers who can talk to you about your experiences and help connect you to expert care. Check out our Patient Resource Center and patient education events at www.kidneycan.org.

Have a KidneyCANDID topic you'd like to see us tackle? Let us know by emailing info@kidneycan.org with KidneyCANDID Topic in the subject line.

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KidneyCAN works to accelerate cures for kidney cancer by providing patient support and education, encouraging enrollment in clinical trials, advocating for research funding from Congress, and sponsoring collaborative efforts between researchers and medical communities.

To learn more about KidneyCAN: https://kidneycan.org​
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Dr. Linehan on Treatment for Hereditary Leiomyomatosis and RCC
Dr. Linehan on Treatment for Hereditary Leiomyomatosis and RCC administrator 4 Views • 2 years ago

What is hereditary leiomyomatosis renal cancer?
What is hereditary leiomyomatosis renal cancer? administrator 3 Views • 2 years ago

What is hereditary leiomyomatosis renal cancer?
Dr. Ulka Vaishampayan, University of Michigan

For more information and resources about kidney cancer, visit www.kidneycancer.org.

Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) - Overview of genetic kidney cancer syndrome
Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) - Overview of genetic kidney cancer syndrome administrator 3 Views • 2 years ago

Visit hlrcc.org for more information

References:

1.) Lu E, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Zavoshi S, Li S, Zhang L, Wilde BR, Christofk HR, Boutros PC, Shuch B. Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. Cancer. 2022 Feb 15;128(4):675-684. doi: 10.1002/cncr.33997. Epub 2021 Nov 1. PMID: 34724198; PMCID: PMC9170268.

2.) Shuch B, Li S, Risch H, Bindra RS, McGillivray PD, Gerstein M. Estimation of the carrier frequency of fumarate hydratase alterations and implications for kidney cancer risk in hereditary leiomyomatosis and renal cancer. Cancer. 2020 Aug 15;126(16):3657-3666. doi: 10.1002/cncr.32914. Epub 2020 May 15. PMID: 32413184.

3.) Menko FH, Maher ER, Schmidt LS, Middelton LA, Aittomäki K, Tomlinson I, Richard S, Linehan WM. Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment. Fam Cancer. 2014 Dec;13(4):637-44. doi: 10.1007/s10689-014-9735-2. PMID: 25012257; PMCID: PMC4574691.

4.) Singh S, Chaurasia A, Gopal N, Malayeri A, Ball MW. Treatment Strategies for Hereditary Kidney Cancer: Current Recommendations and Updates. Discov Med. 2022 Nov-Dec;34(173):205-220. PMID: 36602871.

5.) Gomella PT, Linehan WM, Ball MW. Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management. Genes (Basel). 2021 Feb 11;12(2):261. doi: 10.3390/genes12020261. PMID: 33670168; PMCID: PMC7916897.

6.) Ooi A. Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research. Semin Cancer Biol. 2020 Apr;61:158-166. doi: 10.1016/j.semcancer.2019.10.016. Epub 2019 Nov 2. PMID: 31689495; PMCID: PMC7078051.

Video Animation: Dean Elhag, MD
Script: Dean Elhag, MD & Jason Dicola B.S.
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