Adenomatous polyposis coli tumour suppressor

Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. Here Buchi Okereafor talks to author Mariann Bienz about her Open Biology paper "The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled" and the role APC plays in the development of colorectal cancer.

See http://rsob.royalsocietypublis....hing.org/content/1/3 for the full paper