EKDINKARJA-PATHOLOGYNOTES|GASTRO INTESTINAL STROMAL TUMOUR|GIST|WHO CLASSIFICATION

GIST is a mesenchymal neoplasm with variable behaviour , characterized by differentiation towards the intestinal cells of cajal.

#GIST
#KIT
#PDGFRA


GROSS PATHOLOGY
well circumscribed.

Cut section of large tumours – foci of haemorrhage , cystic change and / or necrosis.

SDH deficient GIST – multi nodular growth pattern.

Invasion of surrounding organs like spleen and pancreas in aggressive tumors.

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