Driver mutations in MPNs and their impact on prognosis: JAK2, MPL, and CALR

Prithviraj Bose, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, highlights the key mutations associated with myeloproliferative neoplasms (MPNs) and how these impact prognosis. Overall, there are three key mutations identified in most patients with MPNs: JAK2, MPL and CALR. However, Dr Bose also explains that some patients also present with other mutations, including DMT3A, AXSL1 and splicing mutations, and are described as triple negatives. To conclude, Dr Bose goes on to discuss how these various mutations impact disease progression and prognosis. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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