Pancanology Explains: Pancreatic Cancer Head Tumor Symptoms, Treatments, and Prognosis

2 Views

07/30/23

So you've got pancreatic cancer located at the head of your pancreas. What does that mean? How does that compare to tumors elsewhere? Watch for pancreatic cancer head tumor diagnosis, symptoms, treatment, surgical, and survival differences.

NCCN Pancreatic Adenocarcinoma Treatment Guidelines: https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1455

#pancreaticcancer

📖 Table of Contents
00:00 Intro
00:18 Disclaimers
00:34 Location
01:53 Symptoms
03:17 Treatments
05:12 Surgery
06:57 Prognosis
07:36 Conclusion

📚 References
[1] Tomasello G et al. Outcome of head compared to body and tail pancreatic cancer: a systematic review and meta-analysis of 93 studies. J Gastrointest Oncol. 2019 Apr;10(2):259-269. https://pubmed.ncbi.nlm.nih.gov/31032093/

[2] NCCN Guidelines Version 1.2022. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1455

[3] Birnbaum DJ et al. Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors. Cancers (Basel). 2019 Apr 8;11(4):497. https://pubmed.ncbi.nlm.nih.gov/30965637/

[4] Zheng Z et al. Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer. PLoS One. 2019 Dec 19;14(12):e0226726. https://pubmed.ncbi.nlm.nih.gov/31856205/

[5] Lee M et al. The Role of Location of Tumor in the Prognosis of the Pancreatic Cancer. Cancers (Basel). 2020 Jul 24;12(8):2036. https://pubmed.ncbi.nlm.nih.gov/32722142/

[6] Sohal DPS et al. Do patients with pancreatic body or tail cancer benefit from adjuvant therapy?A cohort study. Surg Oncol. 2018 Jun;27(2):245-250. https://pubmed.ncbi.nlm.nih.gov/29937178/

[7] Li G et al. Construction and Validation of Novel Nomograms for Predicting Prognosis of Pancreatic Ductal Adenocarcinoma After Surgery According to Different Primary Cancer Locations. Front Oncol. 2021 Apr 23;11:646082. https://pubmed.ncbi.nlm.nih.gov/33968745/

[8] van Erning FN et al.; Dutch Pancreatic Cancer Group. Association of the location of pancreatic ductal adenocarcinoma (head, body, tail) with tumor stage, treatment, and survival: a population-based analysis. Acta Oncol. 2018 Dec;57(12):1655-1662. https://pubmed.ncbi.nlm.nih.gov/30264642/

[9] Ruess DA et al. BMC Surg. 2015 Nov 28;15:123. doi: 10.1186/s12893-015-0110-5. https://pubmed.ncbi.nlm.nih.gov/26615588

[10] Sakin A et al. Factors affecting survival in operated pancreatic cancer: Does tumor localization have a significant effect on treatment outcomes? North Clin Istanb. 2020 Sep 24;7(5):487-493. https://pubmed.ncbi.nlm.nih.gov/33163885/

[11] Winer LK et al. The Impact of Tumor Location on Resection and Survival for Pancreatic Ductal Adenocarcinoma. J Surg Res. 2019 Jul;239:60-66. https://pubmed.ncbi.nlm.nih.gov/30802706/

[12] Watanabe I et al. Onset symptoms and tumor locations as prognostic factors of pancreatic cancer. Pancreas. 2004 Mar;28(2):160-5. https://pubmed.ncbi.nlm.nih.gov/15028948/

[13] Winawer SJ, ed. Management of gastrointestinal diseases. New York: Glower Medical Publishing, 1992.

[14] Porta M et al. Exocrine pancreatic cancer: symptoms at presentation and their relation to tumour site and stage. Clin Transl Oncol. 2005 Jun;7(5):189-97. https://pubmed.ncbi.nlm.nih.gov/15960930/

[15] Eyigor C et al. Does the tumor localization in advanced pancreatic cancer have an influence on the management of symptoms and pain? J BUON. 2010 Jul-Sep;15(3):543-6. https://pubmed.ncbi.nlm.nih.gov/20941825/

[16] Kalser MH et al. Pancreatic cancer. Assessment of prognosis by clinical presentation. Cancer. 1985 Jul 15;56(2):397-402. https://pubmed.ncbi.nlm.nih.gov/4005804/

[17] Goldstein D et al. nab-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial. J Natl Cancer Inst. 2015 Jan 31;107(2):dju413. https://pubmed.ncbi.nlm.nih.gov/25638248/