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Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers mechanism of action and side effects of cell cycle specifc agents including topoisomerase inhibitors (type I & type II) and microtubule inhibitors (vinca alkaloids & taxanes) as well as cell cycle nonspecfic agents including antitumor antibiotics (anthracyclines), alkylating agents (nitrogen mustards, nitrosoureas, triazines, alkyl sulfonates), platinum coordination complexes, tyrosine kinase inhibitors (targeting BCR-ABL, HER2, PDGF, VEGF, EGF receptors), and monoclonal antibodies. Antineoplastic drugs mentioned include; Irinotecan, Topotecan, Etoposide, Vincristine, Vinblastine, Vinorelbine, Paclitaxel, Docetaxel, Cabazitaxel, Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Bleomycin, Chlorambucil, Cyclophosphamide, Ifosfamide, Melphalan, Carmustine, Lomustine, Dacarbazine, Temozolomide, Busulfan, Cisplatin, Carboplatin, Oxaliplatin, Imatinib, Dasatinib, Nilotinib, Lapatinib, Sunitinib, Erlotinib, Trastuzumab, Cetuximab, Bevacizumab, and Rituximab.

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Source of image showing one-electron redox cycle of anthracyclines: https://www.hindawi.com/journals/bmri/2013/751913/

Source of image showing Cisplatin activation and DNA damage induction: http://www.scielo.br/scielo.php?pid=S1807-59322018000200317&script=sci_arttext

0:00 Overview
0:47 Topoisomerase Inhibitors
2:13 Microtubule Inhibitors
4:23 Antitumor Antibiotics
6:38 Alkylating Agents
7:44 Platinum Coordination Complexes
8:42 Tyrosine Kinase Inhibitors
10:41 Monoclonal Antibodies
12:14 Side Effects

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Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers topics such as basic overview of DNA synthesis, de novo pathway for purine and pyrimidine nucleotide synthesis, mechanism of action and side effects of antimetabolites used in treatment of cancer. Covered cancer drugs include Hydroxyurea, Cladribine, Fludarabine, Gemcitabine, Cytarabine, Fluorouracil, Capecitabine, and Methotrexate.

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0:00 Intro
1:18 De novo synthesis of purines
2:59 De novo synthesis of pyrimidines
4:47 Purine antimetabolites
8:29 Pyrimidine antimetabolites
12:52 Side effects

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Cancer is generally defined as the uncontrolled growth of abnormal cells in the body. One of the common approaches in treatment of cancer is to use drugs that target fast-dividing cells at different phases of the cell cycle. This pharmacology lecture covers topics such as main stages of the cell cycle and mitosis, role of estrogen and testosterone in development of cancer, estrogen and androgen receptors, mechanism of action and side effects of anticancer enzymes and hormone therapy used in treatment of prostate and breast cancer. Covered cancer drugs include Anticancer Enzymes: Asparaginase, Pegaspargase; Aromatase Inhibitors: Anastrozole, Letrozole, and Exemestane; Selective Estrogen Receptor Modulators (SERMs): Tamoxifen and Raloxifene; Selective Estrogen Receptor Down-Regulator: Fulvestrant; Gonadotropin-Releasing Hormone (GnRH) Agonists: Leuprolide, Goserelin, and Triptorelin; GnRH Antagonist: Degarelix; Antiandrogens: Flutamide, Bicalutamide, Nilutamide, and Abiraterone.

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0:00 The cell cycle
3:46 Anticancer enzymes
5:13 Estrogen
6:52 Anti-estrogen therapies
9:29 Testosterone
10:14 GnRH antagonists & Antiandrogens
12:18 Side effects

Today’s video is all about oncology pharmacology for Nursing Students and NCLEX Review.

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Many cancer patients have compromised immune systems due to the treatment they’re going through. When administering oncology drugs, you have to know what each medication does and their interactions.

Watch to learn more about cancer pharmacology and how to remember side effects with memorization tips and tricks.

#Pharmacology #Cancer #Chemotherapy

Young man grappling with HIV/AIDS and CANCER. story by Stella Kalekye, uploaded by E.Nyandoro. http://www.kbc.co.ke