Tuberous Sclerosis TSC - An IMBA Human Brain Organoid research model sheds light on the pathology

With the help of cerebral organoids, IMBA scientists were able to ascertain that Tuberous Sclerosis, a rare neurodevelopmental genetic disorder, arises developmentally rather than only genetically. With these patient-derived laboratory models of the human brain, they pinpointed the origin of the disease to progenitor cells specific to humans. The findings, now published in the journal Science, further show that the pathology of diseases affecting the human brain could only be well understood using human-derived brain organoid models.

In this video, IMBA Scientific Director Jürgen Knoblich and IMBA Research Associate in the Knoblich Lab Nina Corsini, both leading authors on the study, provide insights on the impact of their findings. ©IMBA.

Links to the IMBA website for more information on the study:
EN - "Not all brains are equal: Why the human brain is more vulnerable to disease" https://bit.ly/TSC-CLIP
DE - "Nicht alle Gehirne sind gleich: Warum das menschliche Gehirn anfälliger für Krankheiten ist als Tierhirne" https://bit.ly/TSC-CLIP_DE

Original publication:
Eichmüller O.L., Corsini N.S., et al., "Amplification of human interneuron progenitors promotes brain tumors and neurological defects", Science, 2022.
DOI: https://doi.org/10.1126/science.abf5546

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