Redefining low risk high hyperdiploidy in pediatric ALL

Anthony Moorman, PhD, Newcastle University, Newcastle, UK, discusses the findings of a study investigating risk factors which can be used to define a low-risk subgroup of patients with pediatric acute lymphoblastic leukemia (ALL) and high hyperdiploidy. High hyperdiploidy occurs in around 30-35% of cases of B-cell precursor ALL and is strongly associated with good outcomes, however relapses do occur. Prof. Moorman summarizes the key findings of the study and talks on how defining a low-risk subgroup could be used to identify patients eligible for dose escalation. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.