Daratumumab-based frontline therapy in AL amyloidosis: real-world Mayo Clinic experience

Binoy Yohannan, MD, Mayo Clinic, Rochester, MN, shares insights into a real-world study exploring the outcomes of patients with light chain (AL) amyloidosis treated with a bortezomib-based regimen versus daratumumab-based frontline therapy. Patients in the daratumumab arm demonstrated an improvement in hematologic response and organ response, which translated to a superior event-free and overall survival (EFS; OS). These findings further support the use of daratumumab-based frontline therapy in AL amyloidosis. This interview took place at the XIX International Symposium on Amyloidosis (ISA) in Rochester, MN.

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