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Localized amyloidosis: symptoms and site of disease
Localized amyloidosis: symptoms and site of disease administrator 2 Lượt xem • 2 năm trước kia

Localized amyloidosis is typically immunoglobulin light chain ****ociated (AL), although serum amyloid A protein and transthyretin have also been reported as causing localized disease. Localized amyloidosis often involves the laryngo-tracheobronchial tree, urogenital tract, and skin. Eli Muchtar, MD, Mayo Clinic, Rochester, MN, discusses localized amyloidosis compared to systemic amyloidosis, with localized amyloidosis diagnosis based on symptoms and site of localized disease. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).
Diana Williams' husband's battle against rare cancer, Amyloidosis
Diana Williams' husband's battle against rare cancer, Amyloidosis administrator 2 Lượt xem • 2 năm trước kia

Diana Williams wins Mother of the Year after husband's brutal battle with Amyloidosis, a rare cancer.

RELATED: What is amyloidosis? https://7ny.tv/2NJOmGt

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The Amyloidosis Forum | June 21, 2023 | Morning Sessions
The Amyloidosis Forum | June 21, 2023 | Morning Sessions administrator 3 Lượt xem • 2 năm trước kia

Recording of the Morning Sessions from the Amyloidosis Forum: Advancing Drug Development in ATTR Amyloidosis in an Evolving Treatment Landscape, hosted at the U.S. Food and Drug Administration's White Oak Campus in Silver Spring, Maryland on June 21, 2023.

For more information, visit: https://amyloidosisforum.org/a....ttr-drug-development

Each session can be viewed at the following timestamps:

0:00 - Welcome and Introductions
8:32 - Overview of ATTR Amyloidosis and Treatment Advances
38:29 - How Will Shifts in the Stage of Patients with ATTR-CA Affect Ongoing and Future Clinical Trials?
46:29 - Moderated Discussion: How Will Shifts in the Stage of Patients with ATTR-CA Affect Ongoing and Future Clinical Trials?
1:19:27 - What can we collectively do for non-cardiac ATTR drug development?
1:32:19 - Moderated Discussion: What can we collectively do for non-cardiac ATTR drug development?
1:57:07 - Racial and Ethnic Disparities in ATTR
2:06:08 - Moderated Discussion: Racial and Ethnic Disparities in ATTR
2:31:00 - Patient Perspectives: ARC Survey Results
2:45:29 - Patient Perspectives: Today’s Unmet Need
3:47:34 - Moderated Discussion: What Aspect of this Disease Have We Heard from Patients that are Not Being Measured?


Meeting recorded live via Zoom, with some patient interviews pre-recorded and edited.

Greg Foster - Journey to Diagnosis: AL Amyloidosis
Greg Foster - Journey to Diagnosis: AL Amyloidosis administrator 3 Lượt xem • 2 năm trước kia

Greg Foster, 4-time world champion and Olympic Silver medalist, discusses his journey to diagnosis. Learn more about his initial symptoms, multiple doctors visits, and what drove him to continue pursuing an accurate diagnosis of AL Amyloidosis, despite being told he had Athlete's Heart.

Amyloidosis
Amyloidosis administrator 4 Lượt xem • 2 năm trước kia

Amyloidosis
Instructional Tutorial Video
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Amyloidosis Types | 5-minute-review
Amyloidosis Types | 5-minute-review administrator 2 Lượt xem • 2 năm trước kia

Amyloidosis Types | 5-minute-review…Primary amyloidosis vs secondary amyloidosis…Amyloid proteins…Pathology lectures for MBBS, USMLE, COMLEX, NCLEX.
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What is Amyloidosis? | Symptoms, Diagnosis, Treatment | Visual explanation
What is Amyloidosis? | Symptoms, Diagnosis, Treatment | Visual explanation administrator 3 Lượt xem • 2 năm trước kia

This video covers the pathophysiology, presentation, diagnosis and treatment of amyloidosis. This video aimed at helping medical students and junior doctors learn hematology.

In short:
- Amyloidosis is a rare disease characterized by a buildup of abnormal amyloid deposits in the body. Amyloid deposits can build up in the heart, brain, kidneys, spleen and other parts of the body.
- The most common types of amyloidosis are: AL (Primary) Amyloidosis, AA (Secondary) Amyloidosis and ATTR (Familial) Amyloidosis.
- Amyloidosis isn’t curable. Treatment aims to slow amyloid protein production and reduce symptoms.

Timecodes:
0:00 Introduction
0:23 What is Amyloidosis?
0:33 Causes
1:08 Types
2:09 AL - Primary Amyloidosis
3:22 AA - Secondary Amyloidosis
4:02 ATTR - Familial Amyloidosis
4:29 Symptoms
5:21 Diagnosis
6:38 Treatment
8:18 The end

#amyloidosis #hematology #medstudent

Amyloidosis, Causes, Signs and Symptoms, Diagnosis and Treatment.
Amyloidosis, Causes, Signs and Symptoms, Diagnosis and Treatment. administrator 3 Lượt xem • 2 năm trước kia

.

Chapters

0:00 Introduction
1:06 Types and Causes of Amyloidosis
3:15 Symptoms of Amyloidosis
4:04 Diagnosis of Amyloidosis
4:26 Treatment of Amyloidosis


Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue.[4] There are several non-specific and vague signs and symptoms ****ociated with amyloidosis.[5] These include: fatigue, peripheral edema, weight loss, shortness of breath, palpitations, and feeling faint with standing.[5] In AL amyloidosis, specific symptoms can include enlargement of the tongue and periorbital purpura.[5] In wild-type ATTR amyloidosis, non-cardiac symptoms include: bilateral carpal tunnel syndrome, lumbar spinal stenosis, bicep tendon rupture, small fiber neuropathy, and autonomic dysfunction.[5]

There are about 36 different types of amyloidosis, each due to a specific protein misfolding.[6] Within these 36 proteins, 19 are grouped into localized forms, 14 are grouped as systemic forms, and 3 proteins can identify as either.[6] These proteins can become irregular due to genetic effects, as well as through acquired environmental factors.[6] The four most common types of systemic amyloidosis are light chain (AL), inflammation (AA), dialysis-related (Aβ2M), and hereditary and old age (ATTR and familial amyloid polyneuropathy[7]).[2]

Diagnosis may be suspected when protein is found in the urine, organ enlargement is present, or problems are found with multiple peripheral nerves and it is unclear why.[2] Diagnosis is confirmed by tissue biopsy.[2] Due to the variable presentation, a diagnosis can often take some time to reach.[3]

Treatment is geared towards decreasing the amount of the involved protein.[2] This may sometimes be achieved by determining and treating the underlying cause.[2] AL amyloidosis occurs in about 3–13 per million people per year and AA amyloidosis in about 2 per million people per year.[2] The usual age of onset of these two types is 55 to 60 years old.[2] Without treatment, life expectancy is between six months and four years.[2] In the developed world about 1 per 1,000 people die annually from amyloidosis.[3] Amyloidosis has been described since at least 1639.[2]
Causes of Amyloidosis
Causes of Amyloidosis administrator 2 Lượt xem • 2 năm trước kia

Causes of Amyloidosis
Breast cancer in men
Breast cancer in men administrator 3 Lượt xem • 2 năm trước kia

Although rare, men can develop breast cancer. WGN's Dean Richards introduces us to a young man who was shocked to learn the lump he found in his chest was cancer. Dr. Erin Roesch of the Cleveland Clinic also discusses why it's important for men to be aware of the signs of this disease.

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