BAP1 Sarcomatoid Mesothelioma
➡️ http://MesotheliomaUSA.net




The separation of sarcomatous and desmoplastic mesotheliomas from benign organizing pleuritis can be morphologically very difficult. Deletion of p16 (CDKN2A) by fluorescence in situ hybridization (FISH) testing appears to be a reliable marker of malignancy in mesothelial proliferations, and more recently it has been reported that, in this setting, loss of BAP1 by immunohistochemistry is only seen in malignant mesotheliomas. To determine how useful these tests are with sarcomatous and desmoplastic mesotheliomas, we examined 20 such tumors. Loss of BAP1 was seen in 3/20 (15%) and deletion of p16 by FISH was seen in 16/20 (80%) cases. Loss of one or the other marker was observed in 17/20 (85%). We also examined 13 sarcomatoid carcinomas, an important differential diagnosis of sarcomatoid mesotheliomas, and found that BAP1 was never lost, but p16 was deleted in 3/11 (27%). We conclude that: (1) BAP1 immunohistochemistry is relatively insensitive in the context of sarcomatous and desmoplastic mesotheliomas, but as a matter of time and cost efficiency may nonetheless be a useful first approach to the problem; (2) deletion of p16 by FISH is considerably more sensitive, but there remain a proportion of cases in which p16 is not deleted; (3) a small improvement in sensitivity can be achieved by using both markers; (4) in the context of a spindle cell malignant tumor in the pleura or peritoneum, which morphologically might be a metastatic sarcomatoid carcinoma or a mesothelioma, the finding of BAP1 loss favors mesothelioma, but p16 FISH cannot be used to separate sarcomatous mesotheliomas from sarcomatoid carcinomas.

Bap1 Sarcomatoid Mesothelioma - Therapeutic Targets for Mesothelioma and Sarcomatoid Carcinoma
https://www.youtube.com/watch?v=UlreSv-7kP0
https://www.youtube.com/channe....l/UCPhQmbwbQCspqO0e1

#bap1sarcomatoidmesothelioma

🔗 https://pubmed.ncbi.nlm.nih.gov/26900815/

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Mesothelioma is a form of cancer that develops when a layer of squamous cells (known as the mesothelium) surround and suffocate internal organs. Typically, the most affected organ is the lung but it can also occur around the heart or abdomen.

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Mesothelioma and the coroner
➡️ http://MesotheliomaUSA.net




When a person with mesothelioma dies, the doctor who signs the death certificate must inform the coroner, and an inquest has to take place.


In this video:

What is a coroner's inquest?
Why is an inquest needed?
Will the inquest delay a funeral?
Will a post mortem be needed?
Existing compensation claims.
Need support?
How we can help?


What is a coroner's inquest?

There may come a time when treatments are no longer working for your relative or friend and you have to prepare for their death. When someone dies of mesothelioma, there will need to be an inquest. This is a legal investigation into the circumstances surrounding a person’s death. At such a difficult time, it can be even harder if you did not expect this.

Why is an inquest needed?

An inquest is needed because mesothelioma is an occupational disease. When a person with mesothelioma dies, the doctor who signs the death certificate must inform the coroner (the procurator fiscal in Scotland) who will carry out the inquest. A coroner is a doctor or lawyer who investigates unexpected deaths.

Will the inquest delay a funeral?

The need for an inquest will not usually mean any delay before your relative or friend’s funeral can take place. The coroner will issue a temporary death certificate in most cases. This is because a full certificate cannot be issued until after the inquest is completed. This may take a few months.

Will a post mortem be needed?

The coroner will decide if a post mortem (an examination of the body) is needed to find out whether the death was due to mesothelioma or another cause.

In many situations, a post mortem is not needed if there is enough medical evidence to confirm the person had mesothelioma. This evidence may come from samples (biopsies) that were taken when the person was first diagnosed with mesothelioma.

Existing compensation claims.

If your friend or relative was making (or had already made) a compensation claim, the coroner should be told and given the solicitor's details. The solicitor should also be told of the death soon after the person passes away. In most cases, the solicitor will be able to advise and deal with the coroner on behalf of the family.

Need support?

It can be distressing when you have to deal with these issues as well as the possible death of your relative or friend. If you need support - MesotheliomaUSA.net

Mesothelioma and the coroner - What is a coroner's inquest?
https://www.youtube.com/watch?v=T_Fh_Go9mTs
https://www.youtube.com/channe....l/UCqL1ImVqMKM51W4WC

#ismesotheliomaadeathsentence #mesotheliomaandcoroner #mesotheliomacoronerinquest #mesotheliomadeathcoroner

🔗 https://www.macmillan.org.uk/c....ancer-information-an

CLAUDIN 4 MESOTHELIOMA
➡️ http://MesotheliomaUSA.net




Claudin-4 immunohistochemistry is highly effective in distinguishing adenocarcinoma from malignant mesothelioma in effusion cytology.

Background: Adenocarcinoma can be challenging to distinguish from malignant mesothelioma in effusions, and this distinction often requires ancillary studies and clinical correlation. Immunohistochemistry for claudin-4, a tight-junction-associated protein, has recently been shown to distinguish adenocarcinoma from malignant mesothelioma, mostly in surgical specimens. Our aim was to validate and assess the immunoreactivity profile of claudin-4 in a large series of malignant effusions.

Methods: We evaluated 159 malignant effusions (84 adenocarcinomas and 75 malignant mesotheliomas). Claudin-4 immunohistochemistry was performed on cell-block paraffin sections and scored for staining intensity, staining pattern (cytoplasmic versus membranous), and percentage of positive tumor cells. Appropriate positive and negative controls were used throughout.

Results: All cases of mesothelioma were negative for claudin-4 (0 of 64). Eighty-three of 84 cases of adenocarcinoma were positive (99%); 1 case of serous carcinoma was negative. Most adenocarcinomas showed strong and diffuse membranous staining (71 of 84; 84%); 12 cases (14%) showed membranous staining of moderate intensity. The overall sensitivity for adenocarcinoma was 99% (83 of 84).

Conclusions: Claudin-4 immunohistochemistry effectively distinguishes adenocarcinoma from malignant mesothelioma with high sensitivity and specificity in the evaluation of malignant effusions.

Keywords: adenocarcinoma; claudin-4; cytology; effusion; mesothelioma.

CLAUDIN 4 MESOTHELIOMA
https://www.youtube.com/watch?v=_AQMYnUYc-I
https://www.youtube.com/channe....l/UCPhQmbwbQCspqO0e1

#claudin4mesothelioma #intrapleuralchemotherapymesothelioma #aretheredifferenttypesofmesothelioma #howdoyoucheckformesothelioma #asbestosexposuremesothelioma

🔗 https://pubmed.ncbi.nlm.nih.gov/24421209/

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If you or a loved one has been diagnosed with mesothelioma and you are searching for answers, please request your Free Mesothelioma Book by visiting https://www.mesotheliomabook.com/ or calling 1-800-300-6343.

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*** Resources and Links ***
What is mesothelioma? Learn about the different types of mesothelioma, the various stages of mesothelioma, and its causes: https://www.mesotheliomabook.com and https://www.mesotheliomagroup.com/mesothelioma/

What mesothelioma treatments are available? Discover the types of treatments, surgeries, chemotherapy, and radiation treatments: https://www.mesotheliomagroup.com/treatment/

How will I pay for my treatment? There are several types of methods to help pay for the cost of your mesothelioma treatment. Learn more: https://www.mesotheliomagroup.....com/paying-for-treat

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