Yolk Sac Tumor (Endodermal Sinus Tumor) | Mnemonic for USMLE

Yolk sac tumors, also known as endodermal sinus tumors, are aggressive germ cell tumors that often arise in young children. On gross pathology, these tumors have a yellow, friable appearance, and hemorrhage is common. On histology under the microscope, Schiller-Duval bodies resembling renal glomeruli may be seen. Labs will reveal an elevated level of alpha-fetoprotein (AFP), as AFP is secreted by yolk sac cells.

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