Sphingosine-1-phosphate signaling modulation for the treatment of acute myeloid leukemia (AML)

Stephanie Xie from the Princess Margaret Cancer Centre in Toronto, Canada presents on the role of sphingosine 1-phosphate (S1P) signaling in the interplay between normal hematopoiesis, AML and inflammation. She discusses how S1P activation of S1P receptor 3 (S1PR3) is a key process for myeloid lineage differentiation in human HSC that is dysregulated in AML - and functionally shows how modulating this pathway could be an effective and novel therapeutic approach for AML treatment.

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