Overcoming resistance to checkpoint inhibitors in soft tissue sarcomas

Zuzana Střížová, MD, PhD, Charles University, Prague, Czech Republic, discusses potential novel strategies for the management of soft tissue sarcomas. The tumor microenvironment makes immunotherapy unsuitable for treating patients and in an analysis of patients, macrophages were the dominant type of immune cells present. However, combining immune checkpoint inhibitors such as nivolumab and an anti-CD47 antibody has not proven to be efficacious in improving survival. This interview took place at the ESMO Sarcoma and Rare Cancers Congress 2023 in Lugano, Switzerland.

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