Multiple Endocrine Neoplasia Syndrome (MEN I,II,III) / Mnemonic series # 17

Multiple Endocrine Neoplasia Syndrome (MEN I,II,III) / Mnemonic series # 17/ MEN Syndrome
MEN syndrome is an autosomal dominant (AD) predisposition to developing multiple endocrine tumors.

Points to remember:

Parathyroid hyperplasia is common to Men I and Men IIa syndrome.
Medullary carcinoma of thyroid is common to MEN IIa and MEN IIb syndrome.
MEN I occurs due to mutation in Menin I gene located on chromosome 11q.
MEN II occurs due to mutation in Menin II gene located on choromsome 10q.
MEN IV (similar to MEN I) occurs due to mutation in CDKN1B located on chromosome 12p.

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