Multiple Endocrine Neoplasia (MEN 1,2A,2B) Mnemonic || USMLE BOOSTER MD

Multiple Endocrine Neoplasia (MEN 1,2A,2B) Mnemonic || USMLE BOOSTER MD

MEN I (Wermer syndrome)
MEN1 gene mutation
clinical definition: presence of 2 of the 3 P's
parathyroid tumors
increased PTH causes hypercalcemia
results in kidney stones
pituitary tumors (prolactin or GH)
pancreatic islet cell/endocrine tumors
Zollinger-Ellison syndrome
causes gastric ulcers
insulinomas
VIPomas
part of watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome
glucagonomas

MEN II
divided into MEN IIA and IIB
common features
medullary thyroid carcinoma
pheochromocytoma
associated with RET proto-oncogene mutation
gain of function mutation

MEN IIA (Sipple syndrome)
medullary thyroid carcinoma
secretes calcitonin
pheochromocytoma
parathyroid tumors

MEN IIB
medullary thyroid carcinoma
pheochromocytoma