KEYNOTE-966: pembrolizumab + gem/cis vs gemc/cis alone in advanced biliary tract cancer

Changhoon Yoo, MD, PhD, Asan Medical Center, Seoul, Korea, provides an overview of the Phase III KEYNOTE-966 (NCT04003636) trial of pembrolizumab plus gemcitabine and cisplatin versus placebo plus gem/cis for advanced biliary tract cancer (BTC). In this randomized, double-blind, Phase III trial, pembrolizumab plus gemcitabine gem/cis significantly improved overall-survival (OS) versus placebo plus gem/cis and had an expected and manageable safety profile as first-line therapy for unresectable locally advanced or metastatic BTC. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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