Kaposi sarcoma ( Part 4 ) : Transplant associated kaposi sarcoma : USMLE Step 1

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Transplant associated kaposi sarcoma

Occurs months to years after high dose immunosuppressive therapy; 0.2 - 1.0% of kidney transplants
Skin or metastatic lesions present
Skin lesions may regress if immunosuppression is stopped
Usually fatal if spreads to viscera

When KS develops in people whose immune systems have been suppressed after an organ transplant, it is called iatrogenic, or transplant-related KS. Most transplant patients need to take drugs to keep their immune system from rejecting (attacking) the new organ. But by weakening the body’s immune system, these drugs increase the chance that someone infected with KSHV (Kaposi sarcoma--associated herpesvirus) will develop KS. Stopping the immune-suppressing drugs or lowering their dose often makes KS lesions go away or get smaller.

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