How efficacious is CAR-T in childhood AML?

During the 2021 ASCO Annual Meeting, the AML Hub spoke with Hui Zhang, Guangzhou Women and Children's Medical Center, Guangzhou, CN. We asked, How efficacious is CAR-T in childhood AML?

Zhang begins by outlining novel approaches to improve prognosis in relapsed/refractory patients, highlighting the increasing role of CAR T-cell therapy in pediatric AML. He then describes the encouraging results and response rates of his project, presented at ASCO. Finally, Zhang discusses which patients might benefit from CAR T-cell therapy, such as those who are unresponsive to tyrosine kinase inhibitors (TKIs).