How do genetic changes contribute to acute lymphoblastic leukemia (ALL) development?

Know ALL was pleased to speak to Charles Mulligan, St Jude Children's Research Hospital, Memphis, US. We asked, How do genetic changes contribute to acute lymphoblastic leukemia (ALL) development?

Mulligan summarizes how genes are involved in the development of ALL, highlighting genetic predispositions and increased risk in certain groups of people. He discusses the nature of some genetic changes and the environmental factors that may influence the development of ALL. Finally, he outlines the genetic differences in ALL for varying ages and how genetic understanding aids the development of more effective treatments.