Challenges in developing CAR-T cells for liver cancer

Treatment options for liver cancer remain limited, with a handful of small molecule inhibitors and checkpoint inhibitors available for patients. Mitchell Ho, PhD, National Institutes of Health, Bethesda, MD, describes current barriers producing CAR-T cells for hepatocellular carcinoma. The extracellular matrix, tumor microenvironment and cirrhosis are challenges that need to be overcome for efficacious CAR-T cells in the liver. Dr Ho additionally highlights GPC3, a tumor-specific antigen, as well as bispecific antibodies, antibody drug conjugates and natural killer (NK) cell engagers. This interview took place at the 2022 San Antonio Liver Cancer Symposium (SALCS) in San Antonio, TX.

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