CAR-T therapy in multiple myeloma: recent updates, clinical trials and future outlooks

Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, discusses recent updates on the use of CAR-T therapy in multiple myeloma and the value of these agents. Prof. Mohty first highlights the importance of having two CAR-T cells approved in the relapsed/refractory (R/R) setting, namely ciltacabtagene autoleucel (cilta-cel) and idecabtagene vicleucel (ide-cel). Following this, Prof. Mohty discusses important clinical trials in this space, including the KarMMa-3 trial (NCT03651128) and the CARTITUDE-4 trial (NCT04181827), and concludes by highlighting the value of novel GPRC5D and FcRH5-targeted agents. This interview took place at the EBMT-EHA 5th European CAR T-cell Meeting held in Rotterdam, The Netherlands.

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