6 What is the Genetic Basis of GEC? Inherited vs Acquired CDH1 mutation/loss

In this video, Dr. Dan explains the difference between a germline and somatic genetic subset of GEC having CDH1 e-cadherin mutation, and the link of this mutation with diffuse-type gastric cancer. CDH1 mutation is common in diffuse-type gastric cancer, the majority of which are somatic, whereas less than 5% are estimated to be germline.