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6 What is the Genetic Basis of GEC? Inherited vs Acquired CDH1 mutation/loss
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• 06/30/23
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In this video, Dr. Dan explains the difference between a germline and somatic genetic subset of GEC having CDH1 e-cadherin mutation, and the link of this mutation with diffuse-type gastric cancer. CDH1 mutation is common in diffuse-type gastric cancer, the majority of which are somatic, whereas less than 5% are estimated to be germline.
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