3D Video Understanding ATTR Amyloidosis

Hereditary ATTR amyloidosis is caused by a fault or mutation in the transthyretin (TTR) gene which is inherited (i.e. runs in families). The mutation results in an abnormal TTR protein that is unstable and readily misfolds, forming aggregates which deposit as amyloid in various organs and tissues in the body. TTR is mostly made in the liver. Its role is to transport the hormone thyroxine and retinol (Vitamin A) around the body, hence its name transthyretin.

Two main types of ATTR amyloidosis exist:

(1) Hereditary ATTR amyloidosis (hATTR) - Caused by a faulty or mutated gene that is inherited, i.e. runs in the family.
(2) Wild-type ATTR amyloidosis (ATTRwt) - Develops with age; acquired not inherited.

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