Dr. Nizar Bahlis, University of Calgary, presents the results of the ongoing MagnetisMM-3 clinical trial looking at the effects of elranatamab in people with multiple myeloma whose cancer did not respond to treatment at all or came back after responding to previous treatment.

Background:

Elranatamab is a humanized bispecific antibody that targets both B-cell maturation antigen (BCMA)-expressing multiple myeloma (MM) cells and CD3-expressing T cells. MagnetisMM-3 (NCT04649359) is an open-label, multicenter, non-randomized, phase 2 study to evaluate the safety and efficacy of elranatamab monotherapy in patients (pts) with relapsed/refractory MM (RRMM). Results in pts with RRMM and no prior BCMA-targeted treatment (Cohort A) are presented.

Conclusions:

Results suggest that subcutaneous 76 mg QW elranatamab is efficacious and has a manageable safety profile in pts with triple-class- and penta-drug refractory MM and no prior BCMA-targeted treatment. These results support continued development of elranatamab for pts with MM.

Authors:

Nizar Jacques Bahlis, MD, Michael H. Tomasson, MD, Mohamad Mohty, MD PhD, Ruben Niesvizky, MD, Ajay K. Nooka, MD, MPH, FACP, Salomon Manier, MD, PhD, Christopher Maisel, MD, Yogesh Jethava, MD, Joaquin Martinez-Lopez, MD, PhD, H Miles Prince, MD, Bertrand Arnulf, Paula Rodriguez Otero, Guenther Koehne, MD, PhD, Cyrille Touzeau, Noopur Raje, MD, Shinsuke Iida, MD, PhD, Marc-Steffen Raab, Eric Leip, PhD, Sharon Sullivan, PhD, Umberto Conte, PharmD, Andrea Viqueira, MD and Alexander M Lesokhin, MD

ASH Abstract#159: https://ash.confex.com/ash/202....2/webprogram/Paper16

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#Polycythemiavera #MPN #genemutations


Clarifying the MPN Myeloproliferative Neoplasm article New classifications of MPN diagnostics Polycythemia Vera

Clarifying the MPN subgroup
Hi, everyone, I made a quick video to clarify where to see the 8 Subgroups that are mentioned in the article I posted earlier. I hope this helps.

A wonderful #MPN #myeloproliferativeneoplasm article about the 8 Subgroups! The title is so promising!
“New classifications of MPN mean better diagnostics and more definitive prognoses”
I broke it down so we can see where the subgroups are stated.
He is detailed and it is a bit of a difficult read.
The article will definitely give us some questions to ask our doctor or research. This is just wonderful to see his breakdown.
Bless him and his Team!!!
I wish you all health, happiness and a cure!!!
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infograph with the video Highlights on Pinterest:
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Articles referred to in this video:

New classifications of MPN mean better diagnostics and more definitive prognoses
https://www.leukaemia.org.au/m....edia-centre/our-publ

Classification and Personalized Prognosis in Myeloproliferative Neoplasms
Jacob Grinfeld, M.B., Ch.B., Jyoti Nangalia, Ph.D., E. Joanna Baxter, Ph.D., David C. Wedge, Ph.D., Nicos Angelopoulos, Ph.D., Robert Cantrill, Ph.D., Anna L. Godfrey, Ph.D., Elli Papaemmanuil, Ph.D., Gunes Gundem, Ph.D., Cathy MacLean, M.Sc., 
Julia Cook, B.Sc., Laura O’Neil, B.Sc., et al.
https://www.nejm.org/doi/full/....10.1056/NEJMoa171661


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#Polycythemiavera #MPN #spleen #nineandvine #mpn #ninenvinempn #cancer #bloodcancer #polycythemiavera #essentialthrombocythemia #myelofibrosis #myeloproliferativeneoplasm #bloodcancer #bloodcancers #leukemia #myeloproliferativeneoplasm s article

Mariella de Bausset, Secrétaire générale Fondation ARCAD, France
and member of the World Pancreatic Cancer Coalition, shares why it's important to raise awareness of pancreatic cancer.

Lors de la Journée mondiale de la lutte contre le cancer du pancréas, le jeudi 15 novembre, des rassemblements vont avoir lieu dans le monde entier pour en demander plus (Demand BetterSM) en matière de lutte contre le cancer du pancréas, en commençant par le partage d'informations sur les symptômes et les risques.

http://www.worldpancreaticcancerday.org/.


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