Últimos vidéos

A morphomolecular classification of malignant pleural mesothelioma
A morphomolecular classification of malignant pleural mesothelioma administrator 1 vistas • 2 años hace

Lynnette Fernandez-Cuesta, PhD, International Agency for Research on Cancer (IARC-WHO), Lyon, France, discusses how the introduction of a morphomolecular classification of malignant pleural mesothelioma (MPM) could impact clinical management and treatment approaches for this patient population. The recent Omics project published in Nature Genetics suggests a paradigm shift in diagnosing and treating malignant pleural mesothelioma, the findings indicating the need to move away from the current morphological classification and consider a continuum of molecular variation. The study identified four key factors, including morphology, diploidy, immune interaction, and CPG island methylation, as crucial in understanding the disease. Dr Fernandez-Cuesta emphasizes future studies should focus on validating biomarkers to incorporate these factors into clinical treatment. The tumors were classified into three phenotypes representing specialized functions: cell division, tumor immune interaction, and cell cooperation. Immunotherapies may be more effective for tumors specialized in the immune interaction, while targeted therapies require further investigation using advanced techniques like single-cell sequencing. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

MESOTHELIOMA PATHOLOGY - DIFFERENTIAL DIAGNOSIS
MESOTHELIOMA PATHOLOGY - DIFFERENTIAL DIAGNOSIS administrator 5 vistas • 2 años hace

MESOTHELIOMA PATHOLOGY
➡️
http://MesotheliomaUSA.net




Differential diagnosis.

It is important to remember that there are many diseases to be differentiated when making a pathological diagnosis and that the tissue to be differentiated varies in terms of histological type. Epithelioid types must be differentiated from lung adenocarcinoma for pleural mesothelioma, ovarian serous papillary adenocarcinoma or peritoneal serous carcinoma for peritoneal mesothelioma. In terms of sarcomatoid types, sarcoma originating in the chest wall, lung, pleura, abdominal wall, peritoneum and intestine must be excluded. Sarcomatoid carcinoma (spindle cell sarcoma or pleomorphic carcinoma) of the lung is very difficult to differentiate from sarcomatoid pleural mesothelioma. In terms of the biphasic type, carcinosarcoma or pulmonary blastoma of the lung, biphasic synovial sarcoma of the pleural mesothelioma and carcinosarcoma of the female genital organs must be differentiated from their peritoneal counterpart. The desmoplastic type has a similar histology to fibrous pleuritis, and the differential diagnosis is very difficult, particularly if only a small biopsy specimen is available. Reactive mesothelial hyperplasia associated with pleuritis or other lung or pleural disease must be differentiated from early-stage epithelioid mesothelioma.

Usefulness of immunohistochemistry in an accurate diagnosis.

The histochemical staining of hyarulonic acid and electron microscopic studies have been widely used in the past for making a differential diagnosis between mesothelioma and other tumors. However, immunohistochemical stains are currently the method of choice because of the simplicity and ease of these techniques. Many antibodies have been detected for use in immunohistochemical staining techniques aimed at diagnosing mesothelioma, but as yet there is no antibody that is completely specific for mesothelioma and on which a pathological diagnosis of mesothelioma can be singly based. Therefore, the combination of a number of antibodies as positive or negative markers is important, and an assessment of the results in a comprehensive manner is necessary.

In the case of epithelioid mesothelioma, calretinin, WT1, thrombomodulin, mesothelin and D2-40 can be applied as a mesothelial cell marker. CEA, TTF-1, Napsin A and surfactant apoprotein are used as markers for lung adenocarcinoma. In the case of ovarian serous papillary adenocarcinoma, we recommend CEA, Ber-EP4, MOC-31 and ER (estrogen receptor) as positive markers.

The antibodies chosen for sarcomatoid mesothelioma are very different from those used for epithelioid mesothelioma. In the case of sarcomatoid mesothelioma, cytokeratin (AE1/AE3 or CAM5.2 as antibodies) exhibits a high specificity and is the most useful. On the other hand, because the diagnosis for true sarcoma is based on the specific differentiation of tumor cells, mesothelioma is eliminated by making its differentiation clear. For example, the following antibodies are known to be useful: MyoD1, desmin and myoglobin for rhabdomyosarcoma; desmin, α-SMA and h-caldesmon for leiomyosarcoma; S-100p for malignant nerve sheath tumor; KP-1 for malignant fibrous histiocytoma.

The most difficult tumor to be differentiated from sarcomatoid mesothelioma of pleura is sarcomatoid carcinoma (spindle cell carcinoma, pleomorphic carcinoma) of the lung. When immunohistochemical stainings are used, both respond positively to cytokeratin. In this case, therefore, the gross finding or the clinical diagnosis by imaging is very important, as already mentioned.

Immunohistochemical stains may be useful in differentiating between fibrous pleuritis and desmoplastic mesothelioma. Desmin is positive for spindle cells of the fibrous pleuritis, while desmin is negative for tumor cells of the sarcomatoid mesothelioma. The combination of EMA, desmin and p53 is useful for differentiating between reactive mesothelial hyperplasia and early-stage epithelioid mesothelioma. Reactive mesothelial cells are positive for desmin and negative for EMA and p53.

Compensation or relief of patients.

In the compensation system for occupational exposures to asbestos and in the new law for non-occupational exposure to asbestos, if the diagnosis of mesothelioma is certain, it can almost always be presumed to be related to asbestos exposure and the patients can receive compensation or relief. Therefore, the accuracy of the pathological diagnosis as mesothelioma is very important. However, a rough estimate is that approximately 10–15% of mesothelioma patients receive an inadequate diagnosis.

MESOTHELIOMA PATHOLOGY - DIFFERENTIAL DIAGNOSIS
https://www.youtube.com/watch?v=le-QJwv7ij0
https://www.youtube.com/channe....l/UC36qCuQ_tAGvvNv5T

#mesotheliomapathology #mesotheliomapathologymarkers #mesotheliomapathologyoutlines

🔗 https://www.ncbi.nlm.nih.gov/p....mc/articles/PMC26982

5 YEAR SURVIVAL MESOTHELIOMA - MESOTHELIOMA PROGNOSIS
5 YEAR SURVIVAL MESOTHELIOMA - MESOTHELIOMA PROGNOSIS administrator 0 vistas • 2 años hace

5 YEAR SURVIVAL MESOTHELIOMA
➡️
http://MesotheliomaUSA.net




You will find information about the number of people who are diagnosed with mesothelioma each year. You will also read general information on surviving the disease. Remember, survival rates depend on several factors. Use the menu to see other pages.

It is estimated that about 3,000 people are diagnosed with mesothelioma each year in the United States. Mesothelioma occurs more often in men. It is also more common in white and Hispanic people than in Asian American or African American people. The average age for a pleural mesothelioma diagnosis is 72. The number of people diagnosed with mesothelioma in the United States is no longer increasing as it has been in previous decades, and it is now decreasing slightly in men.

The 5-year survival rate tells you what percent of people live at least 5 years after the cancer is found. Percent means how many out of 100. The overall 5-year survival rate for people with mesothelioma is 10% because it is usually diagnosed at a late stage.

If the cancer is found at an early, localized stage, the 5-year survival rate for people with mesothelioma is 18%. If the cancer has spread to nearby areas and/or lymph nodes, the 5-year survival rate is 12%. If the cancer has spread to distant parts of the body, the 5-year survival rate is 7%.

The length of time a person lives after being diagnosed with mesothelioma depends on many factors, including the person’s age. People diagnosed at a younger age often live longer. The type of mesothelioma can also influence survival rates. In particular, some people with peritoneal mesothelioma have a tumor that grows very slowly. People with peritoneal mesothelioma often live longer. People who are able to receive surgery generally live longer than people whose cancer has spread too far to be surgically removed.

It is important to remember that statistics on the survival rates for people with mesothelioma are an estimate. The estimate comes from annual data based on the number of people with this cancer in the United States. Also, experts measure the survival statistics every 5 years. So the estimate may not show the results of better diagnosis or treatment available for less than 5 years. Talk with your doctor if you have any questions about this information.

Statistics adapted from the American Cancer Society website (accessed January 2021).

5 YEAR SURVIVAL MESOTHELIOMA - MESOTHELIOMA PROGNOSIS
https://www.youtube.com/watch?v=2WuYUguLswA
https://www.youtube.com/channe....l/UC36qCuQ_tAGvvNv5T

#5yearsurvivalmesothelioma #5yearsurvivalpleuralmesothelioma #5yearsurvivalratemesothelioma #howlongcanyoulivewithmesotheliomacancer #mesotheliomalongestsurvival #peritonealmesothelioma5yearsurvival #whatarethechancesofsurvivingmesothelioma

🔗 https://www.cancer.net/cancer-....types/mesothelioma/s

How To Detect Mesothelioma? - How To Recognize Mesothelioma Symptoms?
How To Detect Mesothelioma? - How To Recognize Mesothelioma Symptoms? administrator 2 vistas • 2 años hace

How To Detect Mesothelioma?
➡️
http://MesotheliomaUSA.net




Mesothelioma tests include imaging scans, such as chest X-rays and CT scans, blood tests and a biopsy. If a patient shows mesothelioma symptoms, a doctor will conduct a physical exam to check for abnormalities and refer the patient to an oncologist for testing.

What Steps Lead to a Mesothelioma Diagnosis?

1) Symptoms: Symptoms of mesothelioma cause the patient to visit their primary care physician or a hospital for testing.
2) Mesothelioma Testing: The most common first tests are radiology exams such as chest X-rays and CT scans of the chest or abdomen. These initial tests reveal abnormal results, which lead to further.
3) Confirm Diagnosis: The surgeon or oncologist uses a combination of imaging scans, blood tests and biopsies to confirm a mesothelioma diagnosis. A blood test or radiology scans alone cannot confirm a diagnosis of mesothelioma.

There is no clear path to a mesothelioma cancer diagnosis for every patient.

Because the disease is rare and has symptoms similar to other more common and less serious conditions, doctors sometimes confuse it for a different illness or another type of cancer. It is common for patients to be initially misdiagnosed with other conditions before receiving a mesothelioma diagnosis. Pleural mesothelioma can be misdiagnosed as pneumonia or lung cancer, and peritoneal mesothelioma may be misdiagnosed as a more common abdominal cancer.

Providing your doctor with a comprehensive work history is important to the diagnostic process. Doctors are unlikely to suspect the disease unless a patient describes a former job where asbestos exposure may have occurred. Usually, mesothelioma occurs 20-50 years after the initial asbestos exposure.

Researchers are working on ways to detect mesothelioma earlier and with less invasive tools. According to a 2020 review authored by mesothelioma expert Dr. Harvey Pass and others, the potential to diagnose mesothelioma with a breath test might be a reality in the near future.

How to Test for Mesothelioma?

Mesothelioma testing commonly includes imaging scans, biopsies and blood tests. Imaging scans like X-rays and CT scans identify mesothelioma tumors. A biopsy is the only definitive way to confirm a mesothelioma diagnosis. Mesothelioma blood tests are used to measure treatment response.

Imaging tests performed by radiologists reveal the location and extent of mesothelioma tumors. The “gold standard” for mesothelioma imaging is a combination CT-PET scan.

Imaging Tests Commonly Used in Mesothelioma Diagnosis.

X-Rays: Produce basic images of areas with various densities, such as tumors or fluid, within the body.
CT Scans: Also known as CAT scans. These use computer software to integrate hundreds of fine X-ray images to create detailed images of internal structures. These images are much more precise than regular X-rays.
MRIs: Using electromagnetic technology, MRIs generate precise images, which are especially useful when looking at bone, nerve and brain tissue.
PET Scans: These are CT scans where the patient receives an intravenous dose of radioactive glucose, which makes inflamed cells light up on scans. Cell inflammation may be caused by an infection or rapid growth, which could be a sign of cancer.

Mesothelioma Biopsies.

Biopsies are the only way to confirm a mesothelioma diagnosis. The most accurate biopsy technique for mesothelioma is called a thoracoscopy.

Thoracoscopy: While under general anesthesia, the surgeon inserts a small camera between the ribs to suction out the fluid, examine the appearance of the inside of the chest and take biopsies.
Mediastinoscopy: Also under general anesthesia, the surgeon inserts a small camera at the base of the neck to obtain biopsies of the lymph nodes around the windpipe.
Thoracentesis: Under local anesthesia and usually using an ultrasound probe, a small needle is inserted between the ribs in the back to remove pleural fluid buildup around the lungs. It is used to diagnose the cause of pleural effusions.
Fine-Needle Aspiration: Under local anesthesia, a small needle is inserted between the ribs to sample or biopsy tumors while the patient is in the CT scan machine.
Endobronchial Ultrasound-Guided Biopsy: According to a 2016 study, this type of biopsy is helpful at diagnosing pleural mesothelioma when other biopsy techniques can’t obtain a tumor sample.

Mesothelioma blood tests, biomarkers and immunohistochemical markers are not accurate enough to diagnose the cancer alone. They are helpful at monitoring response to treatment.

How To Detect Mesothelioma? - How To Recognize Mesothelioma Symptoms?
https://www.youtube.com/watch?v=acUqlR184Ug
https://www.youtube.com/channe....l/UC36qCuQ_tAGvvNv5T

#howdoyoudetectmesothelioma #howdoyoutestformesothelioma #howtodetectmalignantmesothelioma #howtodetectmesothelioma #howtodetectmesotheliomaearly #howtodetectperitonealmesothelioma

🔗 https://www.asbestos.com/mesothelioma/diagnosis/

Mesothelioma Average Age At Diagnosis - Mesothelioma Prognosis
Mesothelioma Average Age At Diagnosis - Mesothelioma Prognosis administrator 1 vistas • 2 años hace

Mesothelioma Average Age At Diagnosis
➡️
http://MesotheliomaUSA.net




Between 1999 and 2015, there were more than 54,000 documented cases of mesothelioma in the United States. While mesothelioma cancer is rare in relation to many other types of cancer, it has very real consequences for Americans in all walks of life. In fact, many people wonder if they’re part of an age group that is at risk for the disease.

What Is the Average Age at Diagnosis?

The average age of diagnosis for those with mesothelioma is 69 years old. Patients between 80 and 84 experience the highest incidence of mesothelioma, closely followed by the 85-89 age group.

Why Is Mesothelioma Diagnosed Later in Life?

Generally, mesothelioma surfaces later in life due to its long latency period. The condition is notoriously difficult to diagnose because its symptoms don’t appear right away. As the disease progresses, the symptoms that do surface, such as dry coughing, wheezing, and chest pain, are easily mistakable for other illnesses. That’s why it’s important to get tested for mesothelioma if you suspect you may have been exposed to asbestos — the only known cause.

Who Should Be Evaluated for Mesothelioma?

If you notice symptoms of mesothelioma, see a doctor for evaluation right away. If you’ve worked in any of the following industries, you may be at an increased risk for the disease.

Construction: Construction workers were routinely exposed to asbestos products throughout the 20th century. Many of today’s roofing and flooring materials are still made with asbestos.
Firefighters: When fire damages asbestos materials, especially in older buildings, those materials can become airborne.
Industrial Workers: Mechanics, chemical workers, insulators, and machine operators were among the workers most routinely exposed to asbestos in the last century.
Miners: Although mining for asbestos in the U.S. ended in 2002, many miners have since been exposed to it, as minerals including talc are contaminated with asbestos.

Schedule a Case Evaluation With a Mesothelioma Attorney

Those diagnosed with mesothelioma are victims, regardless of their age. If you or someone you love has been diagnosed with this form of cancer, hiring the right legal counsel can make all the difference. The asbestos attorneys at Morgan & Morgan are ready to fight for the compensation and justice you deserve, and hold any responsible parties accountable. We understand what you’re going through and want to be by your side during these trying times. We treat every client like family and extend them the same compassion we would to our own loved ones, ensuring the best possible service. Compensation grants victims and their loved ones the peace of mind necessary to focus on what’s most important. Victims can receive significant compensation from their employer or an asbestos trust fund. Join the Morgan & Morgan family and discover what we can do for you — schedule a free case evaluation with one of our attorneys now.

Mesothelioma Average Age At Diagnosis - Mesothelioma Prognosis
https://www.youtube.com/watch?v=oquy266sjmg
https://www.youtube.com/channe....l/UCqL1ImVqMKM51W4WC

#mesotheliomaprognosis #mesotheliomaaverageage #mesotheliomaagediagnosis

🔗 https://www.forthepeople.com/m....esothelioma-attorney

Malignant Mesothelioma & Asbestos
Malignant Mesothelioma & Asbestos administrator 1 vistas • 2 años hace

Malignant mesothelioma is a disease in which cancer cells are found in the thin layer of tissue that lines the chest cavity and covers the lungs or the thin layer of tissue that lines the abdomen and covers most of the organs in the abdomen.

Many people with malignant mesothelioma have worked or lived in places where they inhaled or swallowed asbestos. After being exposed to asbestos, it can take years for malignant mesothelioma to form.

According to the NIH's National Cancer Institute, possible signs of malignant mesothelioma include shortness of breath and pain under the rib cage. Sometimes the cancer causes fluid to collect around the lung or in the abdomen. These symptoms may be caused by the fluid or malignant mesothelioma although other conditions may also cause the same symptoms. The National Cancer Institute recommends people check with their doctor if you have any of the following problems:

• Trouble breathing
• Pain under the rib cage
• Pain or swelling in the abdomen
• Lumps in the abdomen
• Weight loss for no known reason

Because of its fiber strength and heat resistance, asbestos has been used in a variety of manufactured goods and building construction materials in the past. Asbestos fibers may be released into the air by the disturbance of asbestos-containing material during product use, demolition work, building or home maintenance, repair and remodeling activities. Exposure is most likely to occur when the asbestos-containing material is disturbed or damaged in some way to release particles and fibers into the air. These fibers can then be inhaled by people in the area. Even people who live with a person that worked near or with asbestos may be at increased risk for developing mesothelioma.

In addition to causing mesothelioma, exposure to asbestos can cause lung cancer and asbestosis.

These are just a few things to know about malignant mesothelioma and asbestos. To learn more about this or other indoor air quality, health & safety, and environmental issues, please visit the websites shown in the video.

Showing 3161 out of 3162