Sarcomatoid Mesothelioma - Sarcomatoid Mesothelioma Prognosis

Sarcomatoid Mesothelioma
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Sarcomatoid Mesothelioma Prognosis.

Sarcomatoid mesothelioma has the least favorable prognosis compared to the other common cell types. Studies have shown life expectancies ranging from one month to about 28 months. The majority of patients face a median survival of six months or less.

An individual’s prognosis will also depend on the type of mesothelioma and stage at diagnosis, as well as the patient’s age, gender and overall health.

Patients with biphasic mesothelioma may face a worse prognosis if sarcomatoid cells are more dominant than epithelioid. Biphasic mesothelioma patients typically have a life expectancy of about one year. However, if sarcomatoid cells make up more than 10% of the tumor, patients may have more limited treatment options and a worse prognosis.

Treatment - Sarcomatoid Mesothelioma Treatment.

Research shows sarcomatoid mesothelioma is the most difficult to treat of all cell types. Studies suggest the cells are resistant to many standard therapies. Because malignant sarcomatoid mesothelioma spreads quickly throughout the body, surgery may not be a viable option for many patients.

Chemotherapy is often a first-line treatment for sarcomatoid mesothelioma. Though some studies show the cells can be resistant to chemotherapy, research suggests the treatment may extend survival in some cases.

One study examined 137 pleural sarcomatoid mesothelioma patients between 2000 and 2014. Researchers found:

19 patients had a positive response to chemotherapy treatment, meaning disease progression slowed or stopped during treatment.
Patients with positive responses received chemotherapy as a first-line treatment.
Sarcomatoid patients experienced a 13.9% response rate compared to a 21.9% response rate across all types of mesothelioma.

Immunotherapy treatments have also shown promise in clinical trials for sarcomatoid mesothelioma. Early research suggests it may be an effective option for patients with sarcomatoid mesothelioma who previously received chemotherapy. Some early evidence indicates sarcomatoid mesothelioma may be more responsive to immunotherapy than other cell types.

Radiation therapy may also be applied in some cases. It is often used as a palliative treatment to lessen symptoms and improve a patient’s quality of life.

Research continues to investigate possible treatment combinations to improve life expectancy for sarcomatoid mesothelioma patients.

Sarcomatoid Mesothelioma - Sarcomatoid Mesothelioma Prognosis
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